Kwangwoo Nam1, Jeong Eun Shin1, Sung Eun Kim2, Gwang Ho Baik3, Sang Hyeon Choi3, Ju Yup Lee4, Kyung Sik Park4, Young-Eun Joo5, Dae-Seong Myung5, Hyeon Ju Kim6, Hyun Joo Song7, Suck Chei Choi8, Hyun Jin Kim9, Hyun Young Kim10, Nayoung Kim10,11. 1. a Department of Internal Medicine , Dankook University College of Medicine , Cheonan , South Korea. 2. b Department of Internal Medicine , Kosin University College of Medicine , Busan , South Korea. 3. c Department of Internal Medicine , Hallym University College of Medicine , Chuncheon , South Korea. 4. d Department of Internal Medicine , Keimyung University School of Medicine , Daegu , South Korea. 5. e Department of Internal Medicine , Chonnam National University Medical School , Gwangju , South Korea. 6. f Department of Family Medicine , Jeju National University School of Medicine , Jeju , South Korea. 7. g Department of Internal Medicine , Jeju National University School of Medicine , Jeju , South Korea. 8. h Department of Internal Medicine , Wonkwang University College of Medicine , Iksan , South Korea. 9. i Department of Internal Medicine and Institute of Health Science , Gyeongsang National University School of Medicine , Jinju , South Korea. 10. j Department of Internal Medicine , Seoul National University Bundang Hospital , Seongnam , South Korea. 11. k Department of Internal Medicine , Seoul National University College of Medicine and Liver Research Institute , Seoul , South Korea.
Abstract
OBJECTIVES: The prevalence of upper gastrointestinal disease is expected to change following advances in socioeconomic status and improved hygiene in Korea. The aim of this study was to investigate the recent trends in upper gastrointestinal diseases based on endoscopic findings and Helicobacter pylori (H. pylori) seroprevalence in subjects undergoing health check-up at tertiary centers in Korea. METHODS: A multicenter cross-sectional study was conducted at nine healthcare centers between September 2016 and June 2017. The subjects were evaluated using questionnaires, upper endoscopy and H. pylori serology tests. The results were compared with previous data in our study group obtained from eight tertiary healthcare centers in 2011 (n = 4023). RESULTS: In total, we prospectively enrolled 2504 subjects undergoing health check-up. The prevalence of reflux esophagitis (RE) was 9.7%, which showed an increasing but insignificant trend since 2011 (8.8%). The prevalence of active and healing-stage benign gastric ulcer and duodenal ulcer (DU) was 1.6% and 1.2%, respectively, which confirmed a significant decrease since 2011 (4.1%; p < .001 and 2.2%; p = .005, respectively). The prevalence of gastric cancer was 0.5%, representing an increasing trend since 2011 (0.12%; p = .003). H. pylori seroprevalence was 51.3%, which significantly decreased from 2011 (59.8%; p < .001). In multivariate analysis, H. pylori seropositivity was a significant risk factor for DU (p < .001), whereas a significant protective factor against RE (p < .001). CONCLUSIONS: The significant decrease of H. pylori seroprevalence in the past five years altered the incidence of upper gastrointestinal disease.
OBJECTIVES: The prevalence of upper gastrointestinal disease is expected to change following advances in socioeconomic status and improved hygiene in Korea. The aim of this study was to investigate the recent trends in upper gastrointestinal diseases based on endoscopic findings and Helicobacter pylori (H. pylori) seroprevalence in subjects undergoing health check-up at tertiary centers in Korea. METHODS: A multicenter cross-sectional study was conducted at nine healthcare centers between September 2016 and June 2017. The subjects were evaluated using questionnaires, upper endoscopy and H. pylori serology tests. The results were compared with previous data in our study group obtained from eight tertiary healthcare centers in 2011 (n = 4023). RESULTS: In total, we prospectively enrolled 2504 subjects undergoing health check-up. The prevalence of reflux esophagitis (RE) was 9.7%, which showed an increasing but insignificant trend since 2011 (8.8%). The prevalence of active and healing-stage benign gastric ulcer and duodenal ulcer (DU) was 1.6% and 1.2%, respectively, which confirmed a significant decrease since 2011 (4.1%; p < .001 and 2.2%; p = .005, respectively). The prevalence of gastric cancer was 0.5%, representing an increasing trend since 2011 (0.12%; p = .003). H. pylori seroprevalence was 51.3%, which significantly decreased from 2011 (59.8%; p < .001). In multivariate analysis, H. pylori seropositivity was a significant risk factor for DU (p < .001), whereas a significant protective factor against RE (p < .001). CONCLUSIONS: The significant decrease of H. pylori seroprevalence in the past five years altered the incidence of upper gastrointestinal disease.
Authors: Jun Yeop Lee; Sung Eun Kim; Seun Ja Park; Moo In Park; Won Moon; Jae Hyun Kim; Kyoungwon Jung Journal: Korean J Intern Med Date: 2021-12-16 Impact factor: 2.884
Authors: Eunchan Mun; Daehoon Kim; Yesung Lee; Woncheol Lee; Soyoung Park Journal: Int J Environ Res Public Health Date: 2021-06-08 Impact factor: 3.390