Firass Abiad1, Dalia Khalife2, Bassem Safadi1, Ramzi Alami1, Johnny Awwad2, Fatin Khalifeh2, Ghina Ghazeeri3. 1. Department of General Surgery, American University of Beirut Medical Center, Beirut, Lebanon. 2. Department of Obstetrics & Gynecology, American University of Beirut Medical Center, Beirut, Lebanon. 3. Department of Obstetrics & Gynecology, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address: gg02@aub.edu.lb.
Abstract
AIM: The aims of this study is to address the improvement in CRP and adiponectin in obese PCOS and non PCOS after bariatric surgery, and to show that obese PCOS women have a slower rate of improvement when compared to obese non PCOS women. METHODS: This is a prospective case-control study evaluating the effect of weight loss by sleeve gastrectomy among obese PCOS patients. RESULTS: There was a 36.28% of weight loss among obese PCOS and 33.04% among the control group at 12 months. Both groups showed a significant increase in the adiponectin levels at 3, 6 and 12 months' post-surgery. The rate of increase was higher in the obese non PCOS women (4.93 ± 1.79-9.79 ± 3.9) compared to obese PCOS women (5.05 ± 1.98-7.25 ± 0.21). The CRP levels decreased with weight loss after the surgery to reach statistical significance at 3 months in obese PCOS group (4.18 ± 3.94, p = 0.048). CONCLUSION: The degree of weight loss after surgery was effective in lowering CRP and increasing adiponectin levels in PCOS women. However, this improvement was slower compared to obese non PCOS patients. A genetic predisposition to insulin resistance might explain these findings.
AIM: The aims of this study is to address the improvement in CRP and adiponectin in obese PCOS and non PCOS after bariatric surgery, and to show that obese PCOSwomen have a slower rate of improvement when compared to obese non PCOSwomen. METHODS: This is a prospective case-control study evaluating the effect of weight loss by sleeve gastrectomy among obese PCOSpatients. RESULTS: There was a 36.28% of weight loss among obese PCOS and 33.04% among the control group at 12 months. Both groups showed a significant increase in the adiponectin levels at 3, 6 and 12 months' post-surgery. The rate of increase was higher in the obese non PCOSwomen (4.93 ± 1.79-9.79 ± 3.9) compared to obese PCOSwomen (5.05 ± 1.98-7.25 ± 0.21). The CRP levels decreased with weight loss after the surgery to reach statistical significance at 3 months in obese PCOS group (4.18 ± 3.94, p = 0.048). CONCLUSION: The degree of weight loss after surgery was effective in lowering CRP and increasing adiponectin levels in PCOSwomen. However, this improvement was slower compared to obese non PCOSpatients. A genetic predisposition to insulin resistance might explain these findings.