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Literature DB >> 30168065

Amitriptyline Attenuates Ca²⁺ Responses Induced by Glutoxim and Molixan in Macrophages.

Z I Krutetskaya¹, L S Milenina², A A Naumova², S N Butov², V G Antonov², A D Nozdrachev².

Abstract

Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor agonist, tricyclic antidepressant amitriptyline, significantly inhibits glutoxim- and molixan-induced Ca2+-responses in rat peritoneal macrophages. The results suggest possible involvement of sigma-1 receptors in the signaling cascade induced by glutoxim or molixan and leading to intracellular Ca2+ concentration increase in macrophages.

Entities: Chemical Gene Species

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Year: 2018 PMID： 30168065 DOI： 10.1134/S1607672918040117

Source DB: PubMed Journal: Dokl Biochem Biophys ISSN： 1607-6729 Impact factor: 0.788

13 in total

1. The sigma-1 receptor chaperone as an inter-organelle signaling modulator.

Authors: Tsung-Ping Su; Teruo Hayashi; Tangui Maurice; Shilpa Buch; Arnold E Ruoho
Journal: Trends Pharmacol Sci Date: 2010-10-01 Impact factor: 14.819

2. Cocaine inhibits store-operated Ca2+ entry in brain microvascular endothelial cells: critical role for sigma-1 receptors.

Authors: G Cristina Brailoiu; Elena Deliu; Linda M Console-Bram; Jonathan Soboloff; Mary E Abood; Ellen M Unterwald; Eugen Brailoiu
Journal: Biochem J Date: 2015-10-14 Impact factor: 3.857

3. A new generation of Ca2+ indicators with greatly improved fluorescence properties.

Authors: G Grynkiewicz; M Poenie; R Y Tsien
Journal: J Biol Chem Date: 1985-03-25 Impact factor: 5.157

4. Pharmacological interaction with the sigma1 (σ1)-receptor in the acute behavioral effects of antidepressants.

Authors: Vanessa Villard; Johann Meunier; Nathalie Chevallier; Tangui Maurice
Journal: J Pharmacol Sci Date: 2011 Impact factor: 3.337

5. Calcium influx factor from cytochrome P-450 metabolism and secretion-like coupling mechanisms for capacitative calcium entry in corneal endothelial cells.

Authors: Qiang Xie; Yan Zhang; Changbin Zhai; Joseph A Bonanno
Journal: J Biol Chem Date: 2002-02-26 Impact factor: 5.157

Amitriptyline Attenuates Ca²⁺ Responses Induced by Glutoxim and Molixan in Macrophages.

1. The sigma-1 receptor chaperone as an inter-organelle signaling modulator.

2. Cocaine inhibits store-operated Ca2+ entry in brain microvascular endothelial cells: critical role for sigma-1 receptors.

3. A new generation of Ca2+ indicators with greatly improved fluorescence properties.

4. Pharmacological interaction with the sigma1 (σ1)-receptor in the acute behavioral effects of antidepressants.

5. Calcium influx factor from cytochrome P-450 metabolism and secretion-like coupling mechanisms for capacitative calcium entry in corneal endothelial cells.

6. Citalopram inhibits L-type calcium channel current in rat cardiomyocytes in culture.

7. [THE EFFECT OF EPOXYGENASE INHIBITORS ON Ca(2+)-RESPONSES INDUCED BY GLUTOXIM AND MOLIXAN IN MACROPHAGES].

8. Inhibition of the cardiac L-type calcium channel current by antidepressant drugs.

Review 9. The Role of Sigma-1 Receptor, an Intracellular Chaperone in Neurodegenerative Diseases.

10. Sigma1 receptors inhibit store-operated Ca2+ entry by attenuating coupling of STIM1 to Orai1.

1. Neuroleptic Chlorpromazine Modulates Ca²⁺ Responses in Macrophages.

2. Sigma-1 Receptor Ligands Chlorpromazine and Trifluoperazine Attenuate Ca²⁺ Responses in Rat Peritoneal Macrophages.