Literature DB >> 30168063

Variable Effects of Growth Factors on Developmental Gene Expression in Pancreatic Cancer Cells.

D A Gnatenko1, E P Kopantzev2, E D Sverdlov2.   

Abstract

Stimulation of BxPC-3, Panc-1, and MIA PaCA-2 pancreatic cancer cells with EGF, HGF, FGF-1, FGF-2, FGF-7, and FGF-10 growth factors caused changes in the expression of master genes regulating pancreatic development (SOX9, HNF3b, GATA-4, GATA-6, and HES1). This, in turn, caused changes in the expression profile of important transcription factors, embryonic development regulators. It was also found that the master genes belonging to the same family may cause opposite effects (suppression or enhancement of expression of a particular transcriptional regulator) in the same cell line.

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Year:  2018        PMID： 30168063     DOI： 10.1134/S1607672918040105

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  6 in total

Review 1.  [Fibroblast growth factors and their effects in pancreas organogenesis].

Authors:  D A Gnatenko; E P Kopantzev; E D Sverdlov
Journal:  Biomed Khim       Date:  2017-05

Review 2.  Genetic surgery - a right strategy to attack cancer.

Authors:  Eugene D Sverdlov
Journal:  Curr Gene Ther       Date:  2011-12       Impact factor: 4.391

Review 3.  [Role of fibroblast growth factors in pancreatic cancer].

Authors:  D A Gnatenko; E P Kopantsev; E D Sverdlov
Journal:  Biomed Khim       Date:  2016-11

Review 4.  Phenotype and genotype of pancreatic cancer cell lines.

Authors:  Emily L Deer; Jessica González-Hernández; Jill D Coursen; Jill E Shea; Josephat Ngatia; Courtney L Scaife; Matthew A Firpo; Sean J Mulvihill
Journal:  Pancreas       Date:  2010-05       Impact factor: 3.327

Review 5.  Gene regulatory factors in pancreatic development.

Authors:  Jan Jensen
Journal:  Dev Dyn       Date:  2004-01       Impact factor: 3.780

Review 6.  Growth factors in tumor microenvironment.

Authors:  Xuejing Zhang; Daotai Nie; Subhas Chakrabarty
Journal:  Front Biosci (Landmark Ed)       Date:  2010-01-01
  6 in total
  2 in total

Review 1.  Deciphering role of FGFR signalling pathway in pancreatic cancer.

Authors:  Xiaodiao Kang; Zeng Lin; Minhui Xu; Jun Pan; Zhi-Wei Wang
Journal:  Cell Prolif       Date:  2019-04-03       Impact factor: 6.831

Review 2.  Dissecting FGF Signalling to Target Cellular Crosstalk in Pancreatic Cancer.

Authors:  Edward P Carter; Abigail S Coetzee; Elena Tomas Bort; Qiaoying Wang; Hemant M Kocher; Richard P Grose
Journal:  Cells       Date:  2021-04-08       Impact factor: 6.600
  2 in total

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