Literature DB >> 30168060

Early Deсline in Rat Soleus Passive Tension with Hindlimb Unloading: Inactivation of Cross-bridges or Activation of Calpains?

I O Petrova1, S A Tyganov1, T M Mirzoev1, A K Tsaturyan2, I B Kozlovskaya1, B S Shenkman3.   

Abstract

The study was aimed at testing the hypotheses about the role of cross-bridges and calpains in reduction of rat soleus passive tension under conditions of hindlimb unloading. For this purpose, we used an inhibitor of μ-calpain PD 150606 as well as a blocker of actomyosin interaction (blebbistatin). It was found for the first time that a decrease in passive tension of rat soleus after 3-day hindlimb unloading is associated with the activity of μ-calpain and does not depend on the processes of cross-bridges formation.

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Year:  2018        PMID： 30168060     DOI： 10.1134/S1607672918040075

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  14 in total

1.  Structural and functional studies of titin's fn3 modules reveal conserved surface patterns and binding to myosin S1--a possible role in the Frank-Starling mechanism of the heart.

Authors:  C Muhle-Goll; M Habeck; O Cazorla; M Nilges; S Labeit; H Granzier
Journal:  J Mol Biol       Date:  2001-10-19       Impact factor: 5.469

2.  Passive tension of rat skeletal soleus muscle fibers: effects of unloading conditions.

Authors:  Thierry Toursel; Laurence Stevens; Henk Granzier; Yvonne Mounier
Journal:  J Appl Physiol (1985)       Date:  2002-04

3.  Passive mechanical properties of the medial gastrocnemius muscle of the cat.

Authors:  N P Whitehead; J E Gregory; D L Morgan; U Proske
Journal:  J Physiol       Date:  2001-11-01       Impact factor: 5.182

4.  Skeletal muscle fiber atrophy: altered thin filament density changes slow fiber force and shortening velocity.

Authors:  D A Riley; J L W Bain; J G Romatowski; R H Fitts
Journal:  Am J Physiol Cell Physiol       Date:  2004-10-06       Impact factor: 4.249

5.  A cross-bridge mechanism can explain the thixotropic short-range elastic component of relaxed frog skeletal muscle.

Authors:  K S Campbell; M Lakie
Journal:  J Physiol       Date:  1998-08-01       Impact factor: 5.182

6.  α-Actinin/titin interaction: A dynamic and mechanically stable cluster of bonds in the muscle Z-disk.

Authors:  Marco Grison; Ulrich Merkel; Julius Kostan; Kristina Djinović-Carugo; Matthias Rief
Journal:  Proc Natl Acad Sci U S A       Date:  2017-01-17       Impact factor: 11.205

7.  Thick-filament strain and interfilament spacing in passive muscle: effect of titin-based passive tension.

Authors:  Thomas Irving; Yiming Wu; Tanya Bekyarova; Gerrie P Farman; Norio Fukuda; Henk Granzier
Journal:  Biophys J       Date:  2011-03-16       Impact factor: 4.033

8.  Transversal stiffness of fibers and desmin content in leg muscles of rats under gravitational unloading of various durations.

Authors:  I V Ogneva
Journal:  J Appl Physiol (1985)       Date:  2010-09-09

9.  Changes in stiffness induced by hindlimb suspension in rat soleus muscle.

Authors:  F Canon; F Goubel
Journal:  Pflugers Arch       Date:  1995-01       Impact factor: 3.657

10.  Inhibition of calpain prevents muscle weakness and disruption of sarcomere structure during hindlimb suspension.

Authors:  Jay J Salazar; Daniel E Michele; Susan V Brooks
Journal:  J Appl Physiol (1985)       Date:  2009-11-05
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  3 in total

1.  Calpain-dependent degradation of cytoskeletal proteins as a key mechanism for a reduction in intrinsic passive stiffness of unloaded rat postural muscle.

Authors:  I Y Melnikov; Sergey A Tyganov; K A Sharlo; A D Ulanova; I M Vikhlyantsev; T M Mirzoev; B S Shenkman
Journal:  Pflugers Arch       Date:  2022-08-06       Impact factor: 4.458

Review 2.  How Postural Muscle Senses Disuse? Early Signs and Signals.

Authors:  Boris S Shenkman
Journal:  Int J Mol Sci       Date:  2020-07-16       Impact factor: 5.923

Review 3.  Effects of Various Muscle Disuse States and Countermeasures on Muscle Molecular Signaling.

Authors:  Kristina Sharlo; Sergey A Tyganov; Elena Tomilovskaya; Daniil V Popov; Alina A Saveko; Boris S Shenkman
Journal:  Int J Mol Sci       Date:  2021-12-31       Impact factor: 5.923
  3 in total

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