Literature DB >> 30167932

Cerebrospinal fluid 5-HIAA concentrations correlate with cardiac uptake of 123I-MIBG during myocardial scintigraphy in drug naïve Parkinson's disease.

Hidetomo Murakami1, Ken Yamamoto1, Taro Yasumoto1, Atsushi Kimura1, Yoshiki Sakae1, Shohei Nomoto1, Satomi Kubota1, Daishi Watanabe1, Keiko Watanabe1, Yu Saito1, Satoshi Yano1, Kenjiro Ono2.   

Abstract

We examined the correlations between cerebrospinal fluid (CSF) concentrations of homovanillic acid (HVA) and 5-hydroxyindole acetic acid (5-HIAA) and imaging assessment scores, using 123I-Ioflupane SPECT and 123I-MIBG myocardial scintigraphy in 23 drug naïve PD patients. The CSF 5-HIAA concentration correlated with the H/M ratio of the delayed image (r = 0.458, p < 0.05) and the washout rate (r = - 0.642, p < 0.01) of 123I-MIBG myocardial scintigraphy. These correlations suggest some unclarified pathophysiological links between the central serotonergic and cardiac sympathetic systems.

Entities:  

Keywords:  123I-meta-iodobenzylguanidine myocardial scintigraphy; 5-Hydroxyindoleacetic acid; Biomarker; Cerebrospinal fluid; Lewy body; Parkinson’s disease

Mesh：

Substances：

Year:  2018        PMID： 30167932     DOI： 10.1007/s00702-018-1917-x

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  13 in total

Review 1.  5-HT(1A) receptors in stress-induced cardiac changes: a possible link between mental and cardiac disorders.

Authors:  Eugene Nalivaiko
Journal:  Clin Exp Pharmacol Physiol       Date:  2006-12       Impact factor: 2.557

2.  Quantitative correlation between cardiac MIBG uptake and remaining axons in the cardiac sympathetic nerve in Lewy body disease.

Authors:  Makoto Takahashi; Masako Ikemura; Teruaki Oka; Toshiki Uchihara; Koichi Wakabayashi; Akiyoshi Kakita; Hitoshi Takahashi; Mari Yoshida; Shuta Toru; Takayoshi Kobayashi; Satoshi Orimo
Journal:  J Neurol Neurosurg Psychiatry       Date:  2015-05-02       Impact factor: 10.154

3.  Staging of serotonergic dysfunction in Parkinson's disease: an in vivo 11C-DASB PET study.

Authors:  Marios Politis; Kit Wu; Clare Loane; Lorenzo Kiferle; Sophie Molloy; David J Brooks; Paola Piccini
Journal:  Neurobiol Dis       Date:  2010-05-31       Impact factor: 5.996

4.  Loss of brainstem serotonin- and substance P-containing neurons in Parkinson's disease.

Authors:  G M Halliday; P C Blumbergs; R G Cotton; W W Blessing; L B Geffen
Journal:  Brain Res       Date:  1990-02-26       Impact factor: 3.252

5.  Cerebrospinal fluid metabolite and nigrostriatal dopaminergic function in Parkinson's disease.

Authors:  K Ishibashi; K Kanemaru; Y Saito; S Murayama; K Oda; K Ishiwata; H Mizusawa; K Ishii
Journal:  Acta Neurol Scand       Date:  2009-11-28       Impact factor: 3.209

Review 6.  (123)I-meta-iodobenzylguanidine (MIBG) cardiac scintigraphy in α-synucleinopathies.

Authors:  Satoshi Orimo; Makiko Yogo; Tomohiko Nakamura; Masahiko Suzuki; Hirohisa Watanabe
Journal:  Ageing Res Rev       Date:  2016-02-02       Impact factor: 10.895

7.  Ventricular cerebrospinal fluid monoamine transmitter and metabolite concentrations reflect human brain neurochemistry in autopsy cases.

Authors:  P Wester; U Bergström; A Eriksson; C Gezelius; J Hardy; B Winblad
Journal:  J Neurochem       Date:  1990-04       Impact factor: 5.372

Review 8.  Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium.

Authors:  Ian G McKeith; Bradley F Boeve; Dennis W Dickson; Glenda Halliday; John-Paul Taylor; Daniel Weintraub; Dag Aarsland; James Galvin; Johannes Attems; Clive G Ballard; Ashley Bayston; Thomas G Beach; Frédéric Blanc; Nicolaas Bohnen; Laura Bonanni; Jose Bras; Patrik Brundin; David Burn; Alice Chen-Plotkin; John E Duda; Omar El-Agnaf; Howard Feldman; Tanis J Ferman; Dominic Ffytche; Hiroshige Fujishiro; Douglas Galasko; Jennifer G Goldman; Stephen N Gomperts; Neill R Graff-Radford; Lawrence S Honig; Alex Iranzo; Kejal Kantarci; Daniel Kaufer; Walter Kukull; Virginia M Y Lee; James B Leverenz; Simon Lewis; Carol Lippa; Angela Lunde; Mario Masellis; Eliezer Masliah; Pamela McLean; Brit Mollenhauer; Thomas J Montine; Emilio Moreno; Etsuro Mori; Melissa Murray; John T O'Brien; Sotoshi Orimo; Ronald B Postuma; Shankar Ramaswamy; Owen A Ross; David P Salmon; Andrew Singleton; Angela Taylor; Alan Thomas; Pietro Tiraboschi; Jon B Toledo; John Q Trojanowski; Debby Tsuang; Zuzana Walker; Masahito Yamada; Kenji Kosaka
Journal:  Neurology       Date:  2017-06-07       Impact factor: 9.910

9.  Homovanillic acid and 5-hydroxyindole acetic acid as biomarkers for dementia with Lewy bodies and coincident Alzheimer's disease: An autopsy-confirmed study.

Authors:  Satoru Morimoto; Masaki Takao; Hiroyuki Hatsuta; Yasushi Nishina; Tadashi Komiya; Renpei Sengoku; Yuta Nakano; Akiko Uchino; Hiroyuki Sumikura; Yuko Saito; Kazutomi Kanemaru; Shigeo Murayama
Journal:  PLoS One       Date:  2017-02-06       Impact factor: 3.240

10.  Accumulation of 123I-Ioflupane Is a Useful Marker of the Efficacy of Selegiline Monotherapy in Drug-Naïve Parkinson's Disease.

Authors:  Hidetomo Murakami; Tetsuhito Nohara; Masanobu Uchiyama; Yoshiyuki Owan; Akinori Futamura; Azusa Shiromaru; Setsuro Tsukada; Yu Saito; Takeshi Kuroda; Satoshi Yano; Seiichiro Ishigaki; Hirotaka Katoh; Jiro Munechika; Yoshimitsu Ohgiya; Takehiko Gokan; Kenjiro Ono
Journal:  Front Aging Neurosci       Date:  2017-09-29       Impact factor: 5.750
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