| Literature DB >> 30165651 |
Adriana Weinberg1, Zoran Popmihajlov2, Kenneth E Schmader3, Michael J Johnson1, Yupanqui Caldas1, Adriana Tovar Salazar1, Jennifer Canniff1, Barbara J McCarson2, Jason Martin2, Lei Pang2, Myron J Levin1.
Abstract
Protection against zoster conferred by zoster vaccine live (ZVL; Zostavax) wanes over time. We compared varicella-zoster virus cell-mediated immunity (VZV-CMI) of adults ≥70 years who received a second dose of ZVL ≥10 years after the initial dose with de novo-immunized age-matched controls. Before and during the first year after vaccination, VZV-CMI was significantly higher in reimmunized compared with de novo vaccinees. At 3 years, VZV-CMI differences between groups decreased and only memory responses remained marginally higher in reimmunized participants. In conclusion, the increase in VZV-CMI generated by reimmunization with ZVL is at least equally persistent compared with de novo immunization.Entities:
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Year: 2019 PMID: 30165651 DOI: 10.1093/infdis/jiy514
Source DB: PubMed Journal: J Infect Dis ISSN: 0022-1899 Impact factor: 5.226