| Literature DB >> 30160825 |
Andrew Whyte1, Katherine I Burton1, Jingli Zhang1,2, Mark Lautens1.
Abstract
An enantioselective copper-catalyzed intramolecular borylacylation is reported. The reaction proceeds through an initial enantioselective borylcupration of the styrene, followed by a nucleophilic attack on the tethered carbamoyl chloride. The products, chiral borylated 3,3-disubstituted oxindoles, were generated in excellent yields and enantioselectivities. The versatile carbon-boron bond provides a platform for a wide array of diversification.Entities:
Keywords: asymmetric catalysis; boron; copper; cyclizations; heterocycles
Year: 2018 PMID： 30160825 DOI： 10.1002/anie.201808460
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336