Literature DB >> 3016024

Murine coronavirus-induced encephalomyelitis in rats: analysis of immunoglobulins and virus-specific antibodies in serum and cerebrospinal fluid.

R Dörries, R Watanabe, H Wege, V ter Meulen.   

Abstract

The humoral intrathecal immune response in coronavirus-induced demyelinating encephalomyelitis in rats associated with an autoimmune reaction to brain antigen, was analysed. The CSF of these animals revealed immune reactions which were directed against coronavirus and other, unknown, antigens. In general, no direct correlation between the disease, the state of the blood-brain barrier (BBB), intrathecal synthesis of Ig and the presence of virus-specific antibodies was detectable, suggesting that the humoral, in contrast to the cellular, immune response does not play a significant pathogenetic role in this CNS disease.

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Year:  1986        PMID： 3016024      PMCID： PMC7119894          DOI： 10.1016/0165-5728(86)90026-3

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  31 in total

1.  Progressive rubella virus panencephalitis: synthesis of oligoclonal virus-specific IgG antibodies and homogeneous free light chains in the central nervous system.

Authors:  B Vandvik; M L Weil; M Grandien; E Norrby
Journal:  Acta Neurol Scand       Date:  1978-01       Impact factor: 3.209

2.  Cerebrospinal fluid proteins in neurology.

Authors:  A Lowenthal; R Crols; E De Schutter; J Gheuens; D Karcher; M Noppe; A Tasnier
Journal:  Int Rev Neurobiol       Date:  1984       Impact factor: 3.230

3.  Intrathecal synthesis of virus-specific oligoclonal IgG, IgA and IgM antibodies in a case of varicella-zoster meningoencephalitis.

Authors:  F Vartdal; B Vandvik; E Norrby
Journal:  J Neurol Sci       Date:  1982 Nov-Dec       Impact factor: 3.181

4.  Suboccipital puncture of guinea pigs.

Authors:  H Reiber; O Schunck
Journal:  Lab Anim       Date:  1983-01       Impact factor: 2.471

5.  Local production of mumps IgG and IgM antibodies in the cerebrospinal fluid of meningitis patients.

Authors:  P Ukkonen; M L Granström; J Räsänen; E M Salonen; K Penttinen
Journal:  J Med Virol       Date:  1981       Impact factor: 2.327

6.  Detection and identification of virus-specific, oligoclonal IgG in unconcentrated cerebrospinal fluid by immunoblot technique.

Authors:  R Dörries; V Ter Meulen
Journal:  J Neuroimmunol       Date:  1984-12       Impact factor: 3.478

7.  Antibodies to viral and non-viral antigens in subacute sclerosing panencephalitis and multiple sclerosis demonstrated by thin-layer polyacrylamide gel isoelectric focusing, antigen immunofixation and autoradiography.

Authors:  J Shorr; B Roström; H Link
Journal:  J Neurol Sci       Date:  1981-01       Impact factor: 3.181

8.  Demyelinating encephalomyelitis induced by a long-term corona virus infection in rats. A preliminary report.

Authors:  K Nagashima; H Wege; R Meyermann; V ter Meulen
Journal:  Acta Neuropathol       Date:  1979-03-15       Impact factor: 17.088

9.  Relapsing subacute demyelinating encephalomyelitis in rats during the course of coronavirus JHM infection.

Authors:  H Wege; R Watanabe; V ter Meulen
Journal:  J Neuroimmunol       Date:  1984-08       Impact factor: 3.478

10.  Sequence of murine coronavirus JHM induced neuropathological changes in rats.

Authors:  M Koga; H Wege; V ter Meulen
Journal:  Neuropathol Appl Neurobiol       Date:  1984 May-Jun       Impact factor: 8.090
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  15 in total

1.  T-cell-mediated clearance of mouse hepatitis virus strain JHM from the central nervous system.

Authors:  M A Sussman; R A Shubin; S Kyuwa; S A Stohlman
Journal:  J Virol       Date:  1989-07       Impact factor: 5.103

2.  Population dynamics of lymphocyte subsets in the central nervous system of rats with different susceptibility to coronavirus-induced demyelinating encephalitis.

Authors:  R Dörries; S Schwender; H Imrich; H Harms
Journal:  Immunology       Date:  1991-11       Impact factor: 7.397

3.  The pathogenic role of virus-specific antibody-secreting cells in the central nervous system of rats with different susceptibility to coronavirus-induced demyelinating encephalitis.

Authors:  S Schwender; H Imrich; R Dörries
Journal:  Immunology       Date:  1991-11       Impact factor: 7.397

Review 4.  The impact of the intracerebral antibody response on the clinical course of a virus-induced demyelination in a rat model system.

Authors:  R Dörries; H Imrich; A Hein; S Czub; S Schwender
Journal:  J Neurol Neurosurg Psychiatry       Date:  1994-11       Impact factor: 10.154

Review 5.  Multiple sclerosis: experimental models and reality.

Authors:  Hans Lassmann; Monika Bradl
Journal:  Acta Neuropathol       Date:  2016-10-20       Impact factor: 17.088

6.  Coronavirus-JHM-induced demyelinating encephalomyelitis in rats. Analysis of the intrathecal immune response.

Authors:  R Dörries; S Schwender; H Wege; H Harms; R Watanabe; V ter Meulen
Journal:  Ann N Y Acad Sci       Date:  1988       Impact factor: 5.691

7.  Coronavirus induced primary demyelination: indications for the involvement of a humoral immune response.

Authors:  F Zimprich; J Winter; H Wege; H Lassmann
Journal:  Neuropathol Appl Neurobiol       Date:  1991-12       Impact factor: 8.090

8.  Cervical lymphoid tissue but not the central nervous system supports proliferation of virus-specific T lymphocytes during coronavirus-induced encephalitis in rats.

Authors:  H Imrich; S Schwender; A Hein; R Dörries
Journal:  J Neuroimmunol       Date:  1994-08       Impact factor: 3.478

9.  Comparative analysis of virus-specific antibodies and immunoglobulins in serum and cerebrospinal fluid of subacute measles virus-induced encephalomyelitis (SAME) in rats and subacute sclerosing panencephalitis (SSPE).

Authors:  R Dörries; U G Liebert; V ter Meulen
Journal:  J Neuroimmunol       Date:  1988-10       Impact factor: 3.478

10.  Induction of protective immunity against coronavirus-induced encephalomyelitis: evidence for an important role of CD8+ T cells in vivo.

Authors:  E Flory; M Pfleiderer; A Stühler; H Wege
Journal:  Eur J Immunol       Date:  1993-08       Impact factor: 5.532
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