Vikash Dadlani1, Jordan E Pinsker2, Eyal Dassau2,3,4, Yogish C Kudva5. 1. Endocrine Research Unit, Mayo Clinic, 200 First Street SW, Rochester, MN, 55902, USA. 2. Sansum Diabetes Research Institute, 2219 Bath Street, Santa Barbara, CA, 93105, USA. 3. Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, 29 Oxford St, Cambridge, MA, USA. 4. Joslin Diabetes Center, Boston, MA, USA. 5. Endocrine Research Unit, Mayo Clinic, 200 First Street SW, Rochester, MN, 55902, USA. kudva.yogish@mayo.edu.
Abstract
PURPOSE OF REVIEW: To provide a current review of closed-loop insulin delivery or artificial pancreas (AP) as therapy for people with type 1 diabetes mellitus (T1D) RECENT FINDINGS: The Medtronic Minimed 670G AP system has been in use in clinical practice since March 2017. Currently, Medtronic is conducting a large randomized clinical trial to evaluate its efficacy further in T1D. Simultaneously, the NIH has funded four research consortia to accelerate progress to approval of other AP and decision support systems. Several research groups are currently developing next-generation AP systems, with a number of companies moving toward releasing closed-loop systems in the future. AP systems are also being tested in select populations such as hypoglycemia-unaware T1D and pregnant T1D. AP research is rapidly advancing. The clinical range of AP will be expanded in the next decade.
PURPOSE OF REVIEW: To provide a current review of closed-loop insulin delivery or artificial pancreas (AP) as therapy for people with type 1 diabetes mellitus (T1D) RECENT FINDINGS: The Medtronic Minimed 670G AP system has been in use in clinical practice since March 2017. Currently, Medtronic is conducting a large randomized clinical trial to evaluate its efficacy further in T1D. Simultaneously, the NIH has funded four research consortia to accelerate progress to approval of other AP and decision support systems. Several research groups are currently developing next-generation AP systems, with a number of companies moving toward releasing closed-loop systems in the future. AP systems are also being tested in select populations such as hypoglycemia-unaware T1D and pregnant T1D. AP research is rapidly advancing. The clinical range of AP will be expanded in the next decade.
Authors: Firas H El-Khatib; Courtney Balliro; Mallory A Hillard; Kendra L Magyar; Laya Ekhlaspour; Manasi Sinha; Debbie Mondesir; Aryan Esmaeili; Celia Hartigan; Michael J Thompson; Samir Malkani; J Paul Lock; David M Harlan; Paula Clinton; Eliana Frank; Darrell M Wilson; Daniel DeSalvo; Lisa Norlander; Trang Ly; Bruce A Buckingham; Jamie Diner; Milana Dezube; Laura A Young; April Goley; M Sue Kirkman; John B Buse; Hui Zheng; Rajendranath R Selagamsetty; Edward R Damiano; Steven J Russell Journal: Lancet Date: 2016-12-20 Impact factor: 79.321
Authors: Katharine D Barnard; Timothy Wysocki; Vanessa Ully; Julia K Mader; Thomas R Pieber; Hood Thabit; Martin Tauschmann; Lalantha Leelarathna; Sara Hartnell; Carlo L Acerini; Malgorzata E Wilinska; Sibylle Dellweg; Carsten Benesch; Sabine Arnolds; Manuel Holzer; Harald Kojzar; Fiona Campbell; James Yong; Jennifer Pichierri; Peter Hindmarsh; Lutz Heinemann; Mark L Evans; Roman Hovorka Journal: J Diabetes Sci Technol Date: 2017-04-03
Authors: Mary C M Macintosh; Kate M Fleming; Jaron A Bailey; Pat Doyle; Jo Modder; Dominique Acolet; Shona Golightly; Alison Miller Journal: BMJ Date: 2006-06-16
Authors: P G Jacobs; J El Youssef; R Reddy; N Resalat; D Branigan; J Condon; N Preiser; K Ramsey; M Jones; C Edwards; K Kuehl; J Leitschuh; U Rajhbeharrysingh; J R Castle Journal: Diabetes Obes Metab Date: 2016-08-15 Impact factor: 6.577
Authors: H Thabit; M Tauschmann; J M Allen; L Leelarathna; S Hartnell; M E Wilinska; C L Acerini; S Dellweg; C Benesch; L Heinemann; J K Mader; M Holzer; H Kojzar; J Exall; J Yong; J Pichierri; K D Barnard; C Kollman; P Cheng; P C Hindmarsh; F M Campbell; S Arnolds; T R Pieber; M L Evans; D B Dunger; R Hovorka Journal: N Engl J Med Date: 2015-09-17 Impact factor: 91.245
Authors: Stephanie S Crossen; James P Marcin; Lihong Qi; Hadley S Sauers-Ford; Allison M Reggiardo; Shelby T Chen; Victoria A Tran; Nicole S Glaser Journal: Diabetes Technol Ther Date: 2019-09-18 Impact factor: 6.118
Authors: Ravinder Jeet Kaur; Sunil Deshpande; Jordan E Pinsker; Wesley P Gilliam; Shelly McCrady-Spitzer; Isabella Zaniletti; Donna Desjardins; Mei Mei Church; Francis J Doyle Iii; Walter K Kremers; Eyal Dassau; Yogish C Kudva Journal: Diabetes Technol Ther Date: 2022-04-25 Impact factor: 7.337
Authors: Kelilah L Wolkowicz; Eleonora M Aiello; Eva Vargas; Hazhir Teymourian; Farshad Tehrani; Joseph Wang; Jordan E Pinsker; Francis J Doyle; Mary-Elizabeth Patti; Lori M Laffel; Eyal Dassau Journal: Bioeng Transl Med Date: 2020-12-09