Literature DB >> 30158647

Cytotoxic antibiotic angucyclines and actinomycins from the Streptomyces sp. XZHG99T.

Jie Bao1, Fei He1, Yumei Li1, Lei Fang1, Kaiming Wang1, Jintong Song1, Jie Zhou1, Qiang Li1, Hua Zhang2.   

Abstract

Three new angucycline-type C-glycosides, grincamycins L-N (1-3), together with the known rabelomycin (4), moromycin B (5), fridamycin D (6), saquayamycin B1 (7), actinomycin X2 (8), and actinomycin D (9), were isolated from the culture of the soil-derived Streptomyces sp. XZHG99T collected from Color desert, Dengpa District, Tibet. The structures of 1-3 were established by detailed analyses of comprehensive spectroscopic data. Compounds 1-9 exhibited significant cytotoxicity against a panel of human cancer cell lines A549, H157, MCF7, MDA-MB-231, and HepG2, while 4, 8, and 9 showed decent antibacterial activity against Mycobacterium smegmatis and Staphylococcus aureus.

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Year:  2018        PMID： 30158647     DOI： 10.1038/s41429-018-0096-1

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  7 in total

1.  Activation of anthrachamycin biosynthesis in Streptomyces chattanoogensis L10 by site-directed mutagenesis of rpoB.

Authors:  Zi-Yue Li; Qing-Ting Bu; Jue Wang; Yu Liu; Xin-Ai Chen; Xu-Ming Mao; Yong-Quan Li
Journal:  J Zhejiang Univ Sci B       Date:  2019 Dec.       Impact factor: 3.066

2.  Grincamycins P-T: Rearranged Angucyclines from the Marine Sediment-Derived Streptomyces sp. CNZ-748 Inhibit Cell Lines of the Rare Cancer Pseudomyxoma Peritonei.

Authors:  Zhuo Shang; Zachary E Ferris; Douglas Sweeney; Alexander B Chase; Chunhua Yuan; Yvonne Hui; Lukuan Hou; Ethan A Older; Dan Xue; Xiaoyu Tang; Weipeng Zhang; Prakash Nagarkatti; Mitzi Nagarkatti; Traci L Testerman; Paul R Jensen; Jie Li
Journal:  J Nat Prod       Date:  2021-04-26       Impact factor: 4.050

3.  Streptomyces sp SM01 isolated from Indian soil produces a novel antibiotic picolinamycin effective against multi drug resistant bacterial strains.

Authors:  Pulak Kumar Maiti; Sujoy Das; Prithidipa Sahoo; Sukhendu Mandal
Journal:  Sci Rep       Date:  2020-06-22       Impact factor: 4.379

4.  Molecular Details of Actinomycin D-Treated MRSA Revealed via High-Dimensional Data.

Authors:  Xuewei Xia; Jun Liu; Li Huang; Xiaoyong Zhang; Yunqin Deng; Fengming Li; Zhiyuan Liu; Riming Huang
Journal:  Mar Drugs       Date:  2022-01-31       Impact factor: 5.118

5.  Integrated Metabolomic, Molecular Networking, and Genome Mining Analyses Uncover Novel Angucyclines From Streptomyces sp. RO-S4 Strain Isolated From Bejaia Bay, Algeria.

Authors:  Rima Ouchene; Didier Stien; Juliette Segret; Mouloud Kecha; Alice M S Rodrigues; Carole Veckerlé; Marcelino T Suzuki
Journal:  Front Microbiol       Date:  2022-06-23       Impact factor: 6.064

6.  Draft Genome Sequence of Streptomyces sp. Strain PSAA01, Isolated from the Soil of Eastern Himalayan Foothills.

Authors:  Prasenjit Das; Biraj Sarkar; Amit Ghati; Rittick Mondal; Paulami Dam; Octávio L Franco; Marlon H Cardoso; Ashwani Sharma; Shambhu Swarnakar; Florina Miere Groza; Debnirmalya Gangopadhyay; Sukhendu Mandal; Ahmet Kati; Amit Kumar Mandal
Journal:  Microbiol Resour Announc       Date:  2022-06-27

7.  Diversity and antimicrobial activities of culturable actinomycetes from Odontotermes formosanus (Blattaria: Termitidae).

Authors:  Yanhua Long; Yong Zhang; Fang Huang; Song Liu; Tian Gao; Yinglao Zhang
Journal:  BMC Microbiol       Date:  2022-03-25       Impact factor: 3.605
  7 in total

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