Francesco Soria1,2, David D'Andrea1, Kamal Pohar3, Shahrokh F Shariat1,4,5,6, Yair Lotan6. 1. Department of Urology and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria. 2. Division of Urology, Department of Surgical Sciences, San Giovanni Battista Hospital, University of Studies of Torino, Turin, Italy. 3. Department of Urology, The Ohio State University, Columbus, Ohio, USA. 4. Karl Landsteiner Institute of Urology and Andrology, Vienna, Austria. 5. Department of Urology, Weill Cornell Medical College, New York Presbyterian Hospital, New York. 6. Department of Urology, University of Texas Southwestern Medical Center, Dallas, USA.
Abstract
PURPOSE OF REVIEW: To summarize the current knowledge about the clinical role of novel urinary markers in bladder cancer (BCa) management, from diagnosis to follow-up, from prognosis of oncological outcomes to response to intravesical therapy. RECENT FINDINGS: Urinary markers have been developed to overcome the limitations of the current available tools for the diagnosis and surveillance of BCa patients. However, to date, because of their limited performances, urinary markers are not generally used in clinical practice. For a marker to be of clinical benefit, it needs to be better, easier, faster and cheaper. The differential requirements for a marker's diagnostic performances depend on goals for clinical utility. Their most promising role seems to be in settings such as in case of equivocal cystoscopy/cytology during follow-up of nonmuscle invasive tumors. Newer markers are available or in development using panels of markers of RNA expression or methylation. SUMMARY: To date, there are multiple urine markers that have improved sensitivity over cytology but there is lack of validation of clinical utility. Some of the recently developed markers aim to change the paradigm of BCa follow-up by replacing or reducing the need of invasive investigations. Further prospective validations are needed to confirm these findings.
PURPOSE OF REVIEW: To summarize the current knowledge about the clinical role of novel urinary markers in bladder cancer (BCa) management, from diagnosis to follow-up, from prognosis of oncological outcomes to response to intravesical therapy. RECENT FINDINGS: Urinary markers have been developed to overcome the limitations of the current available tools for the diagnosis and surveillance of BCa patients. However, to date, because of their limited performances, urinary markers are not generally used in clinical practice. For a marker to be of clinical benefit, it needs to be better, easier, faster and cheaper. The differential requirements for a marker's diagnostic performances depend on goals for clinical utility. Their most promising role seems to be in settings such as in case of equivocal cystoscopy/cytology during follow-up of nonmuscle invasive tumors. Newer markers are available or in development using panels of markers of RNA expression or methylation. SUMMARY: To date, there are multiple urine markers that have improved sensitivity over cytology but there is lack of validation of clinical utility. Some of the recently developed markers aim to change the paradigm of BCa follow-up by replacing or reducing the need of invasive investigations. Further prospective validations are needed to confirm these findings.
Authors: Vittorio Fasulo; Marco Paciotti; Massimo Lazzeri; Roberto Contieri; Paolo Casale; Alberto Saita; Giovanni Lughezzani; Pietro Diana; Nicola Frego; Pier Paolo Avolio; Piergiuseppe Colombo; Grazia Maria Elefante; Giorgio Guazzoni; Nicolò Maria Buffi; Michael Bates; Rodolfo Hurle Journal: Front Oncol Date: 2022-01-27 Impact factor: 6.244
Authors: Satoshi Katayama; Keiichiro Mori; Benjamin Pradere; Ekaterina Laukhtina; Victor M Schuettfort; Fahad Quhal; Reza Sari Motlagh; Hadi Mostafaei; Nico C Grossmann; Pawel Rajwa; Marco Moschini; Romain Mathieu; Mohammad Abufaraj; David D'Andrea; Eva Compérat; Martin Haydter; Shin Egawa; Yasutomo Nasu; Shahrokh F Shariat Journal: World J Urol Date: 2021-06-18 Impact factor: 4.226