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Literature DB >> 3015674

Identification of high levels of protein phosphatase-1 in rat liver nuclei.

Abstract

Rat liver nuclei contain a protein phosphatase that is indistinguishable from the catalytic subunit of protein phosphatase-1 in its molecular mass, sensitivity to inhibitor-1 and inhibitor-2 and specificity for the beta-subunit of phosphorylase kinase. This activity is not bound to the outer nuclear membrane, but located within the nucleus. The average level of protein phosphatase-1 activity in nuclei is at least 5-fold higher than its average extranuclear concentration.

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Year: 1986 PMID： 3015674 DOI： 10.1016/0014-5793(86)80741-4

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

20 in total

1. Ser/Thr-specific protein phosphatases are required for both catalytic steps of pre-mRNA splicing.

Authors: J E Mermoud; P Cohen; A I Lamond
Journal: Nucleic Acids Res Date: 1992-10-25 Impact factor: 16.971

2. cAMP-dependent protein kinase phosphorylates and activates nuclear Ca2+-ATPase.

Authors: P J Rogue; J P Humbert; A Meyer; S Freyermuth; M M Krady; A N Malviya
Journal: Proc Natl Acad Sci U S A Date: 1998-08-04 Impact factor: 11.205

3. Perinatal expression of elevated hepatic protein phosphatase type 1 activity levels.

Authors: A Burchell; W J Arion; I I Smith; R Hume
Journal: J Inherit Metab Dis Date: 1990 Impact factor: 4.982

4. Serine/threonine phosphatase 1 modulates the subnuclear distribution of pre-mRNA splicing factors.

Authors: T Misteli; D L Spector
Journal: Mol Biol Cell Date: 1996-10 Impact factor: 4.138

5. Dephosphorylation of the transcriptional cofactor NACA by the PP1A phosphatase enhances cJUN transcriptional activity and osteoblast differentiation.

Authors: William N Addison; Martin Pellicelli; René St-Arnaud
Journal: J Biol Chem Date: 2019-04-04 Impact factor: 5.157

Identification of high levels of protein phosphatase-1 in rat liver nuclei.

1. Ser/Thr-specific protein phosphatases are required for both catalytic steps of pre-mRNA splicing.

2. cAMP-dependent protein kinase phosphorylates and activates nuclear Ca2+-ATPase.

3. Perinatal expression of elevated hepatic protein phosphatase type 1 activity levels.

4. Serine/threonine phosphatase 1 modulates the subnuclear distribution of pre-mRNA splicing factors.

5. Dephosphorylation of the transcriptional cofactor NACA by the PP1A phosphatase enhances cJUN transcriptional activity and osteoblast differentiation.

6. Partial purification and characterization of a type 1 protein phosphatase in purified nuclei of pea plumules.

Review 7. Serine/threonine protein phosphatases.

8. The alpha and gamma 1 isoforms of protein phosphatase 1 are highly and specifically concentrated in dendritic spines.

9. Identification of high levels of type 1 and type 2A protein phosphatases in higher plants.

10. PRL-1, a unique nuclear protein tyrosine phosphatase, affects cell growth.