Literature DB >> 30156147

The Anticancer Effect of Sanguinarine: A Review.

Chenxing Fu1, Guiping Guan1, Hongbing Wang2.   

Abstract

In vitro and in vivo studies have revealed that Sanguinarine has antioxidant, anti-inflammatory, proapoptotic, and growth inhibitory effects on tumor cells of a variety of cancers. Previous research showed that sanguinarine induced apoptosis (cell death) and/or antiproliferative while reducing tumor cell antiangiogenic and anti-invasive properties. This paper describes various sanguinarine anti-cancer mechanisms, including inhibition of erroneously-activated signal transduction pathways, apoptosis, and tumor cell proliferation inhibition. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Entities:  

Keywords:  Sanguinarine; anti-inflammatory; anti-tumor; apoptosis; cancer; pathways.

Mesh：

Substances：

Year:  2018        PMID： 30156147     DOI： 10.2174/1381612824666180829100601

Source DB:  PubMed          Journal:  Curr Pharm Des        ISSN： 1381-6128            Impact factor:   3.116


  8 in total

1.  In Silico Design of Dual-Binding Site Anti-Cholinesterase Phytochemical Heterodimers as Treatment Options for Alzheimer's Disease.

Authors:  Hafsa Amat-Ur-Rasool; Mehboob Ahmed; Shahida Hasnain; Abrar Ahmed; Wayne Grant Carter
Journal:  Curr Issues Mol Biol       Date:  2021-12-29       Impact factor: 2.976

2.  Natural Product Library Screens Identify Sanguinarine Chloride as a Potent Inhibitor of Telomerase Expression and Activity.

Authors:  Siyu Yan; Song Lin; Kexin Chen; Shanshan Yin; Haoyue Peng; Nanshuo Cai; Wenbin Ma; Zhou Songyang; Yan Huang
Journal:  Cells       Date:  2022-04-28       Impact factor: 7.666

3.  The Antiangiogenic Effect of Sanguinarine Chloride on Experimental Choroidal Neovacularization in Mice via Inhibiting Vascular Endothelial Growth Factor.

Authors:  Junxiu Zhang; Ke Mao; Qing Gu; Xingwei Wu
Journal:  Front Pharmacol       Date:  2021-03-15       Impact factor: 5.810

4.  Sanguinarine Reverses Pulmonary Vascular Remolding of Hypoxia-Induced PH via Survivin/HIF1α-Attenuating Kv Channels.

Authors:  Fenling Fan; Yifan Zou; Yousen Wang; Peng Zhang; Xiaoyu Wang; Anthony M Dart; Yuliang Zou
Journal:  Front Pharmacol       Date:  2021-12-24       Impact factor: 5.810

Review 5.  An Update of the Sanguinarine and Benzophenanthridine Alkaloids' Biosynthesis and Their Applications.

Authors:  José Ignacio Laines-Hidalgo; José Armando Muñoz-Sánchez; Lloyd Loza-Müller; Felipe Vázquez-Flota
Journal:  Molecules       Date:  2022-02-18       Impact factor: 4.411

6.  Sanguinarine-Chelerythrine Fraction of Coptis chinensis Exerts Anti-inflammatory Activity in Carrageenan Paw Oedema Test in Rats and Reveals Reduced Gastrotoxicity.

Authors:  Maciej Danielewski; Sylwia Zielińska; Agnieszka Matuszewska; Wojciech Słupski; Maciej Włodarczyk; Izabela Jęśkowiak; Benita Wiatrak; Krzysztof Kowalski; Anna Jezierska-Domaradzka; Piotr Ziółkowski; Adam Szeląg; Beata Nowak
Journal:  Oxid Med Cell Longev       Date:  2022-03-16       Impact factor: 6.543

7.  Sanguinarine Inhibition of TNF-α-Induced CCL2, IKBKE/NF-κB/ERK1/2 Signaling Pathway, and Cell Migration in Human Triple-Negative Breast Cancer Cells.

Authors:  Samia S Messeha; Najla O Zarmouh; Lovely Antonie; Karam F A Soliman
Journal:  Int J Mol Sci       Date:  2022-07-28       Impact factor: 6.208

Review 8.  Alkaloids in Contemporary Drug Discovery to Meet Global Disease Needs.

Authors:  Sharna-Kay Daley; Geoffrey A Cordell
Journal:  Molecules       Date:  2021-06-22       Impact factor: 4.411
  8 in total

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