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Literature DB >> 30150479

In Vitro Activity of PBTZ169 against Multiple Mycobacterium Species.

Jin Shi^1,2, Jie Lu², Shu'an Wen¹, Zhaojing Zong¹, Fengmin Huo¹, Jingjing Luo¹, Qian Liang¹, Yunxu Li¹, Hairong Huang³, Yu Pang³.

Abstract

In this study, we demonstrate that PBTZ169 exhibits significant differences in in vitro activity against multiple Mycobacterium species. The amino acid polymorphism at codon 387 of decaprenylphosphoryl-beta-d-ribose oxidase (DprE1) can be used as a surrogate marker for in vitro susceptibility to PBTZ169 in mycobacteria. In addition, the amino acid substitution at codon 154 in DprE1 may be associated with acquired resistance to PBTZ169 in the Mycobacterium fortuitum mutants.

Entities: Chemical Species

Keywords: DprE1; PBTZ169; mycobacteria; susceptibility

Mesh：

Substances：

Year: 2018 PMID： 30150479 PMCID： PMC6201125 DOI： 10.1128/AAC.01314-18

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

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