Literature DB >> 30150459

Adjunctive Clavulanic Acid Abolishes the Cefazolin Inoculum Effect in an Experimental Rat Model of Methicillin-Sensitive Staphylococcus aureus Endocarditis.

William R Miller1,2, Kavindra V Singh3,2, Cesar A Arias3,2,4,5,6, Barbara E Murray3,2,4.   

Abstract

We tested the ability of clavulanic acid to restore the efficacy of cefazolin against Staphylococcus aureus TX0117, which exhibits the cefazolin inoculum effect (CzIE). In the rat infective endocarditis model, the coadministration of cefazolin plus clavulanic acid resulted in a significant reduction of bacterial counts (7.1 ± 0.5 log10 CFU/g) compared to that with cefazolin alone (2 ± 0.6 log10 CFU/g; P < 0.0001). The addition of a β-lactamase inhibitor may be a viable strategy for overcoming the CzIE.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  Staphylococcus aureus; animal models; cefazolin; clavulanic acid; infective endocarditis; inoculum effect

Mesh：

Substances：

Year:  2018        PMID： 30150459      PMCID： PMC6201062          DOI： 10.1128/AAC.01158-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

1.  Real-time in vivo bioluminescent imaging for evaluating the efficacy of antibiotics in a rat Staphylococcus aureus endocarditis model.

Authors:  Yan Q Xiong; Julie Willard; Jagath L Kadurugamuwa; Jun Yu; Kevin P Francis; Arnold S Bayer
Journal:  Antimicrob Agents Chemother       Date:  2005-01       Impact factor: 5.191

2.  Cefazolin and Staphylococcus aureus endocarditis.

Authors:  D Kaye; W Hewitt; J S Remington; M Turck
Journal:  JAMA       Date:  1977-06-13       Impact factor: 56.272

3.  Comparative outcomes of cefazolin versus nafcillin for methicillin-susceptible Staphylococcus aureus bacteraemia: a prospective multicentre cohort study in Korea.

Authors:  S Lee; K-H Song; S-I Jung; W B Park; S H Lee; Y-S Kim; Y G Kwak; Y K Kim; S M Kiem; H-I Kim; E S Kim; K-H Park; N J Kim; H-C Jang; H B Kim
Journal:  Clin Microbiol Infect       Date:  2017-07-08       Impact factor: 8.067

4.  In Vivo Effects of Cefazolin, Daptomycin, and Nafcillin in Experimental Endocarditis with a Methicillin-Susceptible Staphylococcus aureus Strain Showing an Inoculum Effect against Cefazolin.

Authors:  Esteban C Nannini; Kavindra V Singh; Cesar A Arias; Barbara E Murray
Journal:  Antimicrob Agents Chemother       Date:  2013-06-24       Impact factor: 5.191

5.  Comparative Effectiveness of Cefazolin Versus Nafcillin or Oxacillin for Treatment of Methicillin-Susceptible Staphylococcus aureus Infections Complicated by Bacteremia: A Nationwide Cohort Study.

Authors:  Jennifer S McDanel; Mary-Claire Roghmann; Eli N Perencevich; Michael E Ohl; Michihiko Goto; Daniel J Livorsi; Makoto Jones; Justin P Albertson; Rajeshwari Nair; Amy M J O'Shea; Marin L Schweizer
Journal:  Clin Infect Dis       Date:  2017-07-01       Impact factor: 9.079

Review 6.  Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management.

Authors:  Steven Y C Tong; Joshua S Davis; Emily Eichenberger; Thomas L Holland; Vance G Fowler
Journal:  Clin Microbiol Rev       Date:  2015-07       Impact factor: 26.132

7.  National burden of invasive methicillin-resistant Staphylococcus aureus infections, United States, 2011.

Authors:  Raymund Dantes; Yi Mu; Ruth Belflower; Deborah Aragon; Ghinwa Dumyati; Lee H Harrison; Fernanda C Lessa; Ruth Lynfield; Joelle Nadle; Susan Petit; Susan M Ray; William Schaffner; John Townes; Scott Fridkin
Journal:  JAMA Intern Med       Date:  2013-11-25       Impact factor: 21.873

8.  Relapse of type A beta-lactamase-producing Staphylococcus aureus native valve endocarditis during cefazolin therapy: revisiting the issue.

Authors:  Esteban C Nannini; Kavindra V Singh; Barbara E Murray
Journal:  Clin Infect Dis       Date:  2003-10-01       Impact factor: 9.079

9.  Clinical implications of cefazolin inoculum effect and β-lactamase type on methicillin-susceptible Staphylococcus aureus bacteremia.

Authors:  Shinwon Lee; Ki Tae Kwon; Hye-In Kim; Hyun Ha Chang; Jong-Myung Lee; Pyoeng Gyun Choe; Wan Beom Park; Nam Joong Kim; Myoung-Don Oh; Do Young Song; Shin-Woo Kim
Journal:  Microb Drug Resist       Date:  2014-12       Impact factor: 3.431

10.  Cefazolin versus Nafcillin for Methicillin-Sensitive Staphylococcus aureus Bloodstream Infection in a California Tertiary Medical Center.

Authors:  S Pollett; S M Baxi; G W Rutherford; S B Doernberg; P Bacchetti; H F Chambers
Journal:  Antimicrob Agents Chemother       Date:  2016-07-22       Impact factor: 5.191
View more
  3 in total

1.  Inoculum effect of β-lactam antibiotics.

Authors:  Justin R Lenhard; Zackery P Bulman
Journal:  J Antimicrob Chemother       Date:  2019-10-01       Impact factor: 5.790

2.  Cefazolin Inoculum Effect and Methicillin-Susceptible Staphylococcus aureus Osteoarticular Infections in Children.

Authors:  J Chase McNeil; Lauren M Sommer; Mary Boyle; Patrick Hogan; Jesus G Vallejo; Kristina G Hultén; Anthony R Flores; Sheldon L Kaplan; Stephanie Fritz
Journal:  Antimicrob Agents Chemother       Date:  2020-08-20       Impact factor: 5.191

3.  Tedizolid as Step-Down Therapy following Daptomycin versus Continuation of Daptomycin against Enterococci and Methicillin- and Vancomycin-Resistant Staphylococcus aureus in a Rat Endocarditis Model.

Authors:  Kavindra V Singh; Cesar A Arias; Barbara E Murray
Journal:  Antimicrob Agents Chemother       Date:  2020-04-21       Impact factor: 5.191
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.