Yoshihito Kogure1, Fumie Shigematsu2, Masahide Oki2, Hideo Saka2. 1. Department of Respiratory Medicine, National Hospital Organization Nagoya Medical Center, Nagoya, Japan yo-kogure@umin.ac.jp. 2. Department of Respiratory Medicine, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Abstract
BACKGROUND/AIM: The aim of this study was to evaluate the relationship between T790M status and the characteristics of non-small cell lung cancer (NSCLC) patients undergoing rebiopsy after initial epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) therapy and whether the site of rebiopsy has an effect on the detection rate for T790M in these patients. MATERIALS AND METHODS: We retrospectively reviewed the clinical data from stage IV or recurrent NSCLC patients who harbored EGFR mutations and who had initially received EGFR-TKI at our Center from January 2009 to December 2016. RESULTS: Overall, 129 patients were included. The median age at EGFR-TKI therapy initiation was 73 years and 110 showed progressive disease. The presence of T790M mutation was associated with significantly longer progression-free survival (PFS) and EGFR mutation status. The participants' characteristics and rebiopsy site did not affect the T790M detection rate. CONCLUSION: It is highly recommended that patients with exon 19 deletions and long PFS undergo screening for T790M. Copyright
BACKGROUND/AIM: The aim of this study was to evaluate the relationship between T790M status and the characteristics of non-small cell lung cancer (NSCLC) patients undergoing rebiopsy after initial epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) therapy and whether the site of rebiopsy has an effect on the detection rate for T790M in these patients. MATERIALS AND METHODS: We retrospectively reviewed the clinical data from stage IV or recurrent NSCLCpatients who harbored EGFR mutations and who had initially received EGFR-TKI at our Center from January 2009 to December 2016. RESULTS: Overall, 129 patients were included. The median age at EGFR-TKI therapy initiation was 73 years and 110 showed progressive disease. The presence of T790M mutation was associated with significantly longer progression-free survival (PFS) and EGFR mutation status. The participants' characteristics and rebiopsy site did not affect the T790M detection rate. CONCLUSION: It is highly recommended that patients with exon 19 deletions and long PFS undergo screening for T790M. Copyright
Authors: Daria Gaut; Myung Shin Sim; Yuguang Yue; Brian R Wolf; Phillip A Abarca; James M Carroll; Jonathan W Goldman; Edward B Garon Journal: Clin Lung Cancer Date: 2017-06-20 Impact factor: 4.785
Authors: Geoffrey R Oxnard; Maria E Arcila; Camelia S Sima; Gregory J Riely; Juliann Chmielecki; Mark G Kris; William Pao; Marc Ladanyi; Vincent A Miller Journal: Clin Cancer Res Date: 2010-12-06 Impact factor: 12.531
Authors: Maria E Arcila; Geoffrey R Oxnard; Khedoudja Nafa; Gregory J Riely; Stephen B Solomon; Maureen F Zakowski; Mark G Kris; William Pao; Vincent A Miller; Marc Ladanyi Journal: Clin Cancer Res Date: 2011-01-19 Impact factor: 12.531