You-Jung Choi1, Eue-Keun Choi2, Kyung-Do Han3, Jin-Hyung Jung3, Jiesuck Park1, Euijae Lee1, Wonseok Choe1, So-Ryoung Lee4, Myung-Jin Cha1, Woo-Hyun Lim5, Seil Oh1. 1. Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea. 2. Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea. Electronic address: choiek17@snu.ac.kr. 3. Department of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. 4. Department of Internal Medicine, Soon Chun Hyang University Hospital Seoul, Seoul, Republic of Korea. 5. Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Republic of Korea.
Abstract
BACKGROUND: Atrial fibrillation (AF) and stroke are common in hypertrophic cardiomyopathy (HCM). We aimed to determine the prevalence and incidence of AF and stroke in patients with HCM during a 10-year period. METHODS: Using the Korean National Health Insurance Services database, we identified patients diagnosed with HCM from the entire Korean population between 2005 and 2015. The annual prevalence and incidence of AF and stroke in HCM patients were estimated. RESULTS: The prevalence of AF in HCM patients has gradually increased to 1.6-fold from 13.4% in 2005 to 20.9% in 2015. The incidence of AF ranged from 4.1 to 5.5%, a similar trend was observed for each year in HCM patients. The prevalence of stroke in HCM patients was approximately 10%, while that in HCM patients with AF was about 20%. During 8741 person-years, AF-related stroke occurred in 257 subjects among 2309 HCM patients with new-onset AF. The overall incidence rate of AF-associated stroke was 2.94 per 100 person-years. In subgroup analysis, the incidence rate of AF-associated stroke was 1.49 per 100 person-years in the under 45 year-old group and 1.48 per 100 person-years in the group with CHA2DS2-VASc score of 0 or 1 point in HCM patients. CONCLUSIONS: The prevalence of AF in HCM patients gradually increased over 10 years. The annual risk of AF-associated stroke in HCM was over 1% even in younger patients and those with CHA2DS2-VASc score of 0 or 1 point, which provide evidence to support the prevention of stroke in HCM patients with AF.
BACKGROUND:Atrial fibrillation (AF) and stroke are common in hypertrophic cardiomyopathy (HCM). We aimed to determine the prevalence and incidence of AF and stroke in patients with HCM during a 10-year period. METHODS: Using the Korean National Health Insurance Services database, we identified patients diagnosed with HCM from the entire Korean population between 2005 and 2015. The annual prevalence and incidence of AF and stroke in HCM patients were estimated. RESULTS: The prevalence of AF in HCM patients has gradually increased to 1.6-fold from 13.4% in 2005 to 20.9% in 2015. The incidence of AF ranged from 4.1 to 5.5%, a similar trend was observed for each year in HCM patients. The prevalence of stroke in HCM patients was approximately 10%, while that in HCM patients with AF was about 20%. During 8741 person-years, AF-related stroke occurred in 257 subjects among 2309 HCM patients with new-onset AF. The overall incidence rate of AF-associated stroke was 2.94 per 100 person-years. In subgroup analysis, the incidence rate of AF-associated stroke was 1.49 per 100 person-years in the under 45 year-old group and 1.48 per 100 person-years in the group with CHA2DS2-VASc score of 0 or 1 point in HCM patients. CONCLUSIONS: The prevalence of AF in HCM patients gradually increased over 10 years. The annual risk of AF-associated stroke in HCM was over 1% even in younger patients and those with CHA2DS2-VASc score of 0 or 1 point, which provide evidence to support the prevention of stroke in HCM patients with AF.
Authors: Tiffany T S Ye; Qi Zhuang Siah; Benjamin Y Q Tan; Jamie S Y Ho; Nicholas L X Syn; Yao Hao Teo; Yao Neng Teo; James W Yip; Tiong-Cheng Yeo; Weiqin Lin; Raymond C C Wong; Ping Chai; Bernard Chan; Vijay Kumar Sharma; Leonard L L Yeo; Ching-Hui Sia Journal: J Thromb Thrombolysis Date: 2022-10-03 Impact factor: 5.221
Authors: Matthew R Lozier; Alexandra M Sanchez; John J Lee; Elie M Donath; Vicente E Font; Esteban Escolar Journal: J Atr Fibrillation Date: 2019-12-31