Eleonora Poggiogalle1, Katie E Cherry2, L Joseph Su3, Sangkyu Kim4, Leann Myers5, David A Welsh6, S Michal Jazwinski4, Eric Ravussin7. 1. Pennington Biomedical Research Center, Baton Rouge, LA; Department of Experimental Medicine- Medical Pathophysiology, Food Science and Endocrinology Section, Sapienza University, Rome, Italy. Electronic address: eleonora.poggiogalle@uniroma1.it. 2. Department of Psychology, Louisiana State University, Baton Rouge, LA. 3. Department of Epidemiology, University of Arkansas for Medical Sciences, Little Rock, AR. 4. Tulane Center for Aging and Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA. 5. Department of Global Biostatistics and Data Science, School of Public Health and Tropical Medicine, Tulane University Health Sciences Center, New Orleans, LA. 6. Department of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA. 7. Pennington Biomedical Research Center, Baton Rouge, LA.
Abstract
OBJECTIVES: Body composition alterations occur during aging. The purpose of the present analysis was to explore the functional consequences of the overlap of sarcopenia and osteoporosis, and the potential role of insulin-like growth factor 1 (IGF1) in their development in the oldest old. SETTING AND PARTICIPANTS: Eighty-seven nonagenarians from the Louisiana Healthy Aging Study were included. MEASURES: The definition of sarcopenia was based on appendicular lean mass (ALM). Osteoporosis was diagnosed based on bone mineral density (BMD) T score. Four phenotypes were compared: (1) healthy body composition, that is, nonosteoporotic nonsarcopenic (CO, control group), (2) osteoporotic (O, low BMD T score), (3) sarcopenic (S, low ALM), and (4) osteosarcopenic (OS, low BMD T score and low ALM). Sex- and age-specific IGF1-Standard Deviation Scores (SDS) were calculated. The Continuous Scale-Physical Functional Performance (CS-PFP) test was performed. RESULTS: In OS men, IGF1-SDS values (-0.61 ±0.37 vs -0.04 ± 0.52, P = .02) were lower than those in CO males (control group), whereas IGF1-SDS were similar in the 4 body composition phenotypes in women. In men only, ALM was positively associated with IGF1-SDS values (P = .01) independent of age and C-reactive protein concentration. Regarding bone health, we found no association between IGF1-SDS values and BMD. IGF1-SDS was not associated with functional performance (CS-PFP) in men and women. CONCLUSIONS/IMPLICATIONS: IGF1 sensitivity in skeletal muscle and bone may differ by sex in the oldest old. IGF1 status did not appear to affect physical functionality. Determinants and clinical and functional characteristics of osteosarcopenia need to be further investigated in order to define conclusive diagnostic criteria.
OBJECTIVES: Body composition alterations occur during aging. The purpose of the present analysis was to explore the functional consequences of the overlap of sarcopenia and osteoporosis, and the potential role of insulin-like growth factor 1 (IGF1) in their development in the oldest old. SETTING AND PARTICIPANTS: Eighty-seven nonagenarians from the Louisiana Healthy Aging Study were included. MEASURES: The definition of sarcopenia was based on appendicular lean mass (ALM). Osteoporosis was diagnosed based on bone mineral density (BMD) T score. Four phenotypes were compared: (1) healthy body composition, that is, nonosteoporotic nonsarcopenic (CO, control group), (2) osteoporotic (O, low BMD T score), (3) sarcopenic (S, low ALM), and (4) osteosarcopenic (OS, low BMD T score and low ALM). Sex- and age-specific IGF1-Standard Deviation Scores (SDS) were calculated. The Continuous Scale-Physical Functional Performance (CS-PFP) test was performed. RESULTS: In OS men, IGF1-SDS values (-0.61 ±0.37 vs -0.04 ± 0.52, P = .02) were lower than those in CO males (control group), whereas IGF1-SDS were similar in the 4 body composition phenotypes in women. In men only, ALM was positively associated with IGF1-SDS values (P = .01) independent of age and C-reactive protein concentration. Regarding bone health, we found no association between IGF1-SDS values and BMD. IGF1-SDS was not associated with functional performance (CS-PFP) in men and women. CONCLUSIONS/IMPLICATIONS: IGF1 sensitivity in skeletal muscle and bone may differ by sex in the oldest old. IGF1 status did not appear to affect physical functionality. Determinants and clinical and functional characteristics of osteosarcopenia need to be further investigated in order to define conclusive diagnostic criteria.
Authors: R N Baumgartner; K M Koehler; D Gallagher; L Romero; S B Heymsfield; R R Ross; P J Garry; R D Lindeman Journal: Am J Epidemiol Date: 1998-04-15 Impact factor: 4.897
Authors: Pauline M Camacho; Steven M Petak; Neil Binkley; Bart L Clarke; Steven T Harris; Daniel L Hurley; Michael Kleerekoper; E Michael Lewiecki; Paul D Miller; Harmeet S Narula; Rachel Pessah-Pollack; Vin Tangpricha; Sunil J Wimalawansa; Nelson B Watts Journal: Endocr Pract Date: 2016-09-02 Impact factor: 3.443
Authors: Anne B Newman; Varant Kupelian; Marjolein Visser; Eleanor Simonsick; Bret Goodpaster; Michael Nevitt; Stephen B Kritchevsky; Frances A Tylavsky; Susan M Rubin; Tamara B Harris Journal: J Am Geriatr Soc Date: 2003-11 Impact factor: 5.562
Authors: D Rudman; P J Drinka; C R Wilson; D E Mattson; F Scherman; M C Cuisinier; S Schultz Journal: Clin Endocrinol (Oxf) Date: 1994-05 Impact factor: 3.478
Authors: M A Papadakis; D Grady; D Black; M J Tierney; G A Gooding; M Schambelan; C Grunfeld Journal: Ann Intern Med Date: 1996-04-15 Impact factor: 25.391
Authors: Peggy M Cawthon; Katherine W Peters; Michelle D Shardell; Robert R McLean; Thuy-Tien L Dam; Anne M Kenny; Maren S Fragala; Tamara B Harris; Douglas P Kiel; Jack M Guralnik; Luigi Ferrucci; Stephen B Kritchevsky; Maria T Vassileva; Stephanie A Studenski; Dawn E Alley Journal: J Gerontol A Biol Sci Med Sci Date: 2014-05 Impact factor: 6.053
Authors: Maryam Kazemi; Brittany Y Jarrett; Stephen A Parry; Anna E Thalacker-Mercer; Kathleen M Hoeger; Steven D Spandorfer; Marla E Lujan Journal: J Clin Endocrinol Metab Date: 2020-09-01 Impact factor: 5.958
Authors: Stephanie R Dayer; Simon C Mears; Amanda K Pangle; Priya Mendiratta; Jeanne Y Wei; Gohar Azhar Journal: Geriatr Orthop Surg Rehabil Date: 2021-08-03
Authors: Myong-Won Seo; Sung-Woo Jung; Sung-Woo Kim; Hyun Chul Jung; Deog-Yoon Kim; Jong Kook Song Journal: Int J Environ Res Public Health Date: 2020-09-10 Impact factor: 3.390