I P Sousa1, F M Burlandy1, S T S Lima2, A C B Maximo2, M A A Figueiredo3, Z Maia4, E E da Silva5. 1. Instituto Oswaldo Cruz, Rio de Janeiro, Brazil. 2. Laboratório Central de Saúde Pública do Ceará, Ceará, Brazil. 3. Divisão de Vigilância Epidemiológica do Estado da Bahia, Bahia, Brazil. 4. Laboratório Central de Saúde Pública Prof. Gonçalo Muniz, Bahia, Brazil. 5. Instituto Oswaldo Cruz, Rio de Janeiro, Brazil. Electronic address: edson@ioc.fiocruz.br.
Abstract
OBJECTIVES: To describe an outbreak of acute myalgia accompanied by elevated levels of muscle enzymes that occurred in the northeast region of Brazil from December 2016 through to May 2017. METHODS: Clinical data were analysed and laboratory tests were performed in 86 specimens obtained from 52 individuals with suspected acute myalgia. A broader reactive enterovirus real-time RT-PCR followed by a semi-nested PCR amplification of partial VP1 gene were performed to identify the causative agent. RESULTS: Eighty-six clinical samples were received in our laboratory during the myalgia outbreak. Median age of individuals was 39 years. Sudden acute myalgia and dark urine were the most common symptoms. Creatine phosphokinase levels were elevated with mean value ∼16 893 U/L. Human enterovirus was detected in 67% (58/86) of the patient's specimens (urine, serum, faeces and rectal swab). The enterovirus positivity per patient was 82.7% (43/52). Echovirus 30 (E-30) (82% of the typed specimens, 18/22; 76.4% (13/17) of the typed specimens per patient) was the main enterovirus identified. In addition to E-30, CV-A16 (1/22) and E-6 (3/22) were detected in 4% and 14% of the typed specimens, respectively. No deaths occurred. CONCLUSION: The 2016-2017 outbreak of acute myalgia that occurred in the northeast region of Brazil can be associated with E-30. Despite the clinical manifestations, a favourable outcome was observed for all patients.
OBJECTIVES: To describe an outbreak of acute myalgia accompanied by elevated levels of muscle enzymes that occurred in the northeast region of Brazil from December 2016 through to May 2017. METHODS:Clinical data were analysed and laboratory tests were performed in 86 specimens obtained from 52 individuals with suspected acute myalgia. A broader reactive enterovirus real-time RT-PCR followed by a semi-nested PCR amplification of partial VP1 gene were performed to identify the causative agent. RESULTS: Eighty-six clinical samples were received in our laboratory during the myalgia outbreak. Median age of individuals was 39 years. Sudden acute myalgia and dark urine were the most common symptoms. Creatine phosphokinase levels were elevated with mean value ∼16 893 U/L. Human enterovirus was detected in 67% (58/86) of the patient's specimens (urine, serum, faeces and rectal swab). The enterovirus positivity per patient was 82.7% (43/52). Echovirus 30 (E-30) (82% of the typed specimens, 18/22; 76.4% (13/17) of the typed specimens per patient) was the main enterovirus identified. In addition to E-30, CV-A16 (1/22) and E-6 (3/22) were detected in 4% and 14% of the typed specimens, respectively. No deaths occurred. CONCLUSION: The 2016-2017 outbreak of acute myalgia that occurred in the northeast region of Brazil can be associated with E-30. Despite the clinical manifestations, a favourable outcome was observed for all patients.
Authors: Raiana S Machado; Francisco Gomes-Neto; Maria L Aguiar-Oliveira; Fernanda M Burlandy; Fernando N Tavares; Edson E da Silva; Ivanildo P Sousa Journal: Viruses Date: 2022-04-26 Impact factor: 5.818
Authors: Ivanildo P Sousa; Maria de Lourdes Aguiar Oliveira; Fernanda M Burlandy; Raiana S Machado; Silas S Oliveira; Fernando N Tavares; Francisco Gomes-Neto; Eliane V da Costa; Edson E da Silva Journal: Emerg Microbes Infect Date: 2020-12 Impact factor: 7.163
Authors: Ivanildo Pedro de Sousa; Heloísa Ihle Giamberardino; Sonia Mara Raboni; Maria Carmo Debur; Maria de Lourdes Aguiar Oliveira; Fernanda Marcicano Burlandy; Edson Elias da Silva Journal: Virol J Date: 2021-04-30 Impact factor: 4.099
Authors: Endrya do Socorro Fôro Ramos; Ulisses Alves Rosa; Geovani de Oliveira Ribeiro; Fabiola Villanova; Flávio Augusto de Pádua Milagres; Rafael Brustulin; Vanessa Dos Santos Morais; Mayara Bertanhe; Roberta Marcatti; Emerson Luiz Lima Araújo; Steven S Witkin; Eric Delwart; Adriana Luchs; Antonio Charlys da Costa; Élcio Leal Journal: Viruses Date: 2021-03-31 Impact factor: 5.048