Literature DB >> 3014845

Separate purinoceptors mediate enhancement by adenosine of concanavalin A-induced mediator release and the cyclic AMP response in rat mast cells.

P J Hughes, M K Church.   

Abstract

Adenosine caused a concentration-related enhancement of concanavalin A (Con A)-induced 5-hydroxytryptamine (5-HT) release from rat purified peritoneal mast cells. This was accompanied by an enhancement and prolongation of the cyclic AMP response to Con A. The cyclic AMP response but not enhancement of 5-HT release was blocked by 8-phenyltheophylline suggesting the two events to be unrelated. The effects of AMP and ADP, adenosine analogues and adenosine uptake inhibitors suggest the enhancement of 5-HT release to be mediated by a P1-cell surface purinoceptor which does not show the characteristics of either A1 or A2 subtypes.

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Year:  1986        PMID： 3014845     DOI： 10.1007/bf01987989

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  4 in total

1.  Role of adenylate cyclase in immunologic release of mediators from rat mast cells: agonist and antagonist effects of purine- and ribose-modified adenosine analogs.

Authors:  S T Holgate; R A Lewis; K F Austen
Journal:  Proc Natl Acad Sci U S A       Date:  1980-11       Impact factor: 11.205

2.  Adenosine potentiates immunological histamine release from rat mast cells by a novel cyclic AMP-independent cell-surface action.

Authors:  M K Church; P J Hughes
Journal:  Br J Pharmacol       Date:  1985-05       Impact factor: 8.739

3.  The relationship between cyclic AMP changes and histamine release from basophil-rich human leucocytes.

Authors:  P J Hughes; S T Holgate; S Roath; M K Church
Journal:  Biochem Pharmacol       Date:  1983-09-01       Impact factor: 5.858

4.  Modulation of cyclic AMP in purified rat mast cells. III. Studies on the effects of concanavalin A and anti-IgE on cyclic AMP concentrations during histamine release.

Authors:  T J Sullivan; K L Parker; A Kulczycki; C W Parker
Journal:  J Immunol       Date:  1976-09       Impact factor: 5.422
  4 in total
  4 in total

Review 1.  Adenosine bronchoconstriction in asthma: investigations into its possible mechanism of action.

Authors:  W H Ng; R Polosa; M K Church
Journal:  Br J Clin Pharmacol       Date:  1990       Impact factor: 4.335

2.  Dual actions of adenosine on rat peritoneal mast cells.

Authors:  M J Lohse; K Maurer; H P Gensheimer; U Schwabe
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-05       Impact factor: 3.000

3.  Inosine binds to A3 adenosine receptors and stimulates mast cell degranulation.

Authors:  X Jin; R K Shepherd; B R Duling; J Linden
Journal:  J Clin Invest       Date:  1997-12-01       Impact factor: 14.808

4.  Synergistic effects of calcium-mobilizing agents and adenosine on histamine release from rat peritoneal mast cells.

Authors:  M J Lohse; K Maurer; K N Klotz; U Schwabe
Journal:  Br J Pharmacol       Date:  1989-12       Impact factor: 8.739
  4 in total

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