| Literature DB >> 30145706 |
Patricia Alves Reis1, Karla Ceodaro Pais2,3, Monica Farah Pereira1, Bruno Douradinha4, Natália Ferreira Costa2, Carlos Roland Kaiser3, Patricia Torres Bozza1, André Luiz Lisboa Areas5, Mariano Gustavo Zalis5, Marcelle de Lima Ferreira2,3, Marcos Vinícius Nora de Souza2, Valber da Silva Frutuoso1, Hugo Caire de Castro-Faria-Neto1.
Abstract
Antimalarial interventions mostly rely upon drugs, as chloroquine. However, plasmodial strains resistant to many drugs are constantly reported, leading to an expansion of malaria cases. Novel approaches are required to circumvent the drug resistance issue. Here, we describe the antimalarial potential of the chloroquine analogue 2-[[2-[(7-chloro-4-quinolinyl)amino]ethyl]amino] ethanol (PQUI08001/06). We observed that PQUI08001/06 treatment reduces parasitemia of both chloroquine-resistant and -sensitive strains of Plasmodium falciparum in vitro and P. berghei in vivo. Our data suggests that PQUI08001/06 is a potential antimalarial therapeutic alternative approach that could also target chloroquine-resistant plasmodial strains.Entities:
Keywords: Antimalarial drug; Chloroquine; Chloroquine resistance; Malaria; Plasmodium
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Year: 2018 PMID： 30145706 DOI： 10.1007/s00436-018-6057-6
Source DB: PubMed Journal: Parasitol Res ISSN： 0932-0113 Impact factor: 2.289