Yu Sawada1, Makoto Araie2, Hitomi Shibata3, Makoto Ishikawa3, Toyoto Iwata4, Takeshi Yoshitomi3. 1. Department of Ophthalmology, Akita University Graduate School of Medicine, Akita, Japan. Electronic address: sawadayu@doc.med.akita-u.ac.jp. 2. Kanto Central Hospital of the Mutual Aid Association of Public School Teachers, Tokyo, Japan. 3. Department of Ophthalmology, Akita University Graduate School of Medicine, Akita, Japan. 4. Department of Environmental Health Sciences, Akita University Graduate School of Medicine, Akita, Japan.
Abstract
PURPOSE: To investigate optic disc margin anatomic features in myopic eyes with open-angle glaucoma (OAG) using spectral-domain (SD) OCT. DESIGN: Cross-sectional study. PARTICIPANTS: Two hundred four eyes of 102 participants with OAG and 106 eyes of 53 participants without glaucoma with axial length of 24 mm or more. METHODS: Radial SD OCT B-scans centered on the optic discs were acquired in each eye, and the SD OCT data were colocalized with the optic disc stereophotographs. Optic disc margin anatomic features were evaluated as (1) SD OCT structure coinciding with the disc margin identified in the stereophotograph, (2) border tissue configuration, and (3) presence of Bruch's membrane overhang, and their frequency was computed in each clock-hour position. Further, paired eyes of myopic participants with OAG were divided into eyes with better or worse visual field defect (VFD), according to the mean deviation of the Humphrey visual field test, and associated factors were compared. MAIN OUTCOME MEASURES: Spectral-domain OCT structures coinciding with the visible optic disc margin in stereophotographs. RESULTS: In myopic eyes with OAG, mean axial length was 25.96±1.07 mm and mean deviation was -8.87±7.78 dB. In approximately 90% of the participants, anterior scleral opening (ASO) coincided with the temporal disc margin and Bruch's membrane opening (BMO) with the nasal disc margin. Border tissue configuration was externally oblique in the temporal region and internally oblique in the nasal region of the optic disc. Bruch's membrane overhang was observed in a relatively small percentage of eyes. The same pattern of disc margin anatomic features was observed in the myopic eyes without glaucoma. The myopic optic disc was shaped by the temporal shifting of the BMO from the ASO, and the extent of shifting was expressed as the width of γ zone parapapillary atrophy (PPA). The greater γ zone PPA width was associated significantly with the worse VFD between paired eyes. CONCLUSIONS: The myopic eyes with OAG exhibited characteristic optic disc margin anatomic features that was considered to be derived from myopic deformation of the eye. The greater γ zone PPA width may increase susceptibility to the glaucomatous stress.
PURPOSE: To investigate optic disc margin anatomic features in myopic eyes with open-angle glaucoma (OAG) using spectral-domain (SD) OCT. DESIGN: Cross-sectional study. PARTICIPANTS: Two hundred four eyes of 102 participants with OAG and 106 eyes of 53 participants without glaucoma with axial length of 24 mm or more. METHODS: Radial SD OCT B-scans centered on the optic discs were acquired in each eye, and the SD OCT data were colocalized with the optic disc stereophotographs. Optic disc margin anatomic features were evaluated as (1) SD OCT structure coinciding with the disc margin identified in the stereophotograph, (2) border tissue configuration, and (3) presence of Bruch's membrane overhang, and their frequency was computed in each clock-hour position. Further, paired eyes of myopic participants with OAG were divided into eyes with better or worse visual field defect (VFD), according to the mean deviation of the Humphrey visual field test, and associated factors were compared. MAIN OUTCOME MEASURES: Spectral-domain OCT structures coinciding with the visible optic disc margin in stereophotographs. RESULTS: In myopic eyes with OAG, mean axial length was 25.96±1.07 mm and mean deviation was -8.87±7.78 dB. In approximately 90% of the participants, anterior scleral opening (ASO) coincided with the temporal disc margin and Bruch's membrane opening (BMO) with the nasal disc margin. Border tissue configuration was externally oblique in the temporal region and internally oblique in the nasal region of the optic disc. Bruch's membrane overhang was observed in a relatively small percentage of eyes. The same pattern of disc margin anatomic features was observed in the myopic eyes without glaucoma. The myopic optic disc was shaped by the temporal shifting of the BMO from the ASO, and the extent of shifting was expressed as the width of γ zone parapapillary atrophy (PPA). The greater γ zone PPA width was associated significantly with the worse VFD between paired eyes. CONCLUSIONS: The myopic eyes with OAG exhibited characteristic optic disc margin anatomic features that was considered to be derived from myopic deformation of the eye. The greater γ zone PPA width may increase susceptibility to the glaucomatous stress.
Authors: Ebenezer Daniel; Victoria Addis; Maureen G Maguire; Brendan McGeehan; Min Chen; Rebecca J Salowe; Selam Zenebe-Gete; Elana Meer; Roy Lee; Eli Smith; Harini V Gudiseva; Prithvi S Sankar; Joan M O'Brien Journal: Ophthalmol Glaucoma Date: 2022-02-10
Authors: Yong Woo Kim; Jin Ju Choi; Michael J A Girard; Jean Martial Mari; Dong Gyu Choi; Ki Ho Park Journal: Invest Ophthalmol Vis Sci Date: 2021-04-01 Impact factor: 4.799