Literature DB >> 3014478

Production and quality control of the Oka-strain live varicella vaccine.

E D'Hondt, E Berge, G Colinet, M Duchene, J Peetermans.   

Abstract

The Smith Kline-RIT live attenuated Oka-strain varicella vaccine (Varilrix) is manufactured following the seed lot principle, with each vaccine lot derived from the same working seed. Production of the vaccine basically consists in the multiplication of the working seed under standardized, well-defined conditions guaranteeing consistency of the vaccine lots. Quality control tests, determining the vaccine's purity, safety, potency, and efficacy, are carried out at each defined stage of the production process.

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Substances：

Year:  1985        PMID： 3014478

Source DB:  PubMed          Journal:  Postgrad Med J        ISSN： 0032-5473            Impact factor:   2.401


  9 in total

1.  Stable and consistent genetic profile of Oka varicella vaccine virus is not linked with appearance of infrequent breakthrough cases postvaccination.

Authors:  Ventzislav Vassilev
Journal:  J Clin Microbiol       Date:  2005-10       Impact factor: 5.948

2.  Novel genetic variation identified at fixed loci in ORF62 of the Oka varicella vaccine and in a case of vaccine-associated herpes zoster.

Authors:  Mark L Quinlivan; Nancy J Jensen; Kay W Radford; D Scott Schmid
Journal:  J Clin Microbiol       Date:  2012-02-29       Impact factor: 5.948

3.  Population diversity in batches of the varicella Oka vaccine.

Authors:  R K Kanda; M L Quinlivan; A A Gershon; R A Nichols; J Breuer
Journal:  Vaccine       Date:  2011-02-22       Impact factor: 3.641

4.  Vaccination to prevent varicella and shingles.

Authors:  J Breuer
Journal:  J Clin Pathol       Date:  2001-10       Impact factor: 3.411

5.  Genetic profile of an Oka varicella vaccine virus variant isolated from an infant with zoster.

Authors:  Andreas Sauerbrei; Elena Rubtcova; Peter Wutzler; D Scott Schmid; Vladimir N Loparev
Journal:  J Clin Microbiol       Date:  2004-12       Impact factor: 5.948

6.  Reactogenicity to a live attenuated varicella vaccine in Canadian children.

Authors:  F Diaz-Mitoma; S A Halperin; D Scheifele
Journal:  Can J Infect Dis       Date:  2000-03

7.  Complete DNA sequences of two oka strain varicella-zoster virus genomes.

Authors:  Sueli L Tillieux; Wendy S Halsey; Elizabeth S Thomas; John J Voycik; Ganesh M Sathe; Ventzislav Vassilev
Journal:  J Virol       Date:  2008-09-10       Impact factor: 5.103

8.  Comparison of the Whole-Genome Sequence of an Oka Varicella Vaccine from China with Other Oka Vaccine Strains Reveals Sites Putatively Critical for Vaccine Efficacy.

Authors:  Qiuhua Wu; Pierre Rivailler; Songtao Xu; Wenbo Xu
Journal:  J Virol       Date:  2019-04-17       Impact factor: 5.103

9.  Deep Sequencing of Distinct Preparations of the Live Attenuated Varicella-Zoster Virus Vaccine Reveals a Conserved Core of Attenuating Single-Nucleotide Polymorphisms.

Authors:  Daniel P Depledge; Koichi Yamanishi; Yasuyuki Gomi; Anne A Gershon; Judith Breuer
Journal:  J Virol       Date:  2016-09-12       Impact factor: 6.549
  9 in total

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