| Literature DB >> 3014412 |
J Schulman, G A Peyman, M B Horton, J Liu, R Fiscella, J Pulido, J C Barber, P de Miranda.
Abstract
Clearance studies in rabbits following intravitreal injection of 400 micrograms of 9-([2-Hydroxy-1-(hydroxymethyl)ethoxy]methyl) guanine demonstrated levels of the antiviral at 60 hours above the in vitro ID50 for several strains of human cytomegalovirus. Intravitreal administration of this new antiviral may have therapeutic application in the treatment of acute retinal necrosis and cytomegalovirus retinitis complicating acquired immune deficiency syndrome (AIDS).Entities:
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Year: 1986 PMID： 3014412
Source DB: PubMed Journal: Ophthalmic Surg ISSN： 0022-023X