| Literature DB >> 30143931 |
Hui Shi1, Guanjun Dong1, Fenglian Yan1, Hui Zhang1, Chunxia Li1, Qun Ma1, Junfeng Zhang1, Zhaochen Ning1, Zhihua Li1, Jun Dai1, Jiankuo Ming1, Runping Fang2, Chuanping Si1, Huabao Xiong3,4.
Abstract
Endotoxin shock is a life-threatening response caused by a disordered immune response to an infection. MDSCs are accumulated and play a protective role in the pathogenesis of endotoxin shock. However, the regulation of MDSCs by small molecule remains unrevealed. Here, we report that arctigenin, a small molecule extracted from Arctium lappa, induces accumulation of functional MDSCs. Arctigenin was able to ameliorate LPS-induced inflammation through accumulating MDSCs, especially granulocytic MDSCs (G-MDSCs), and enhancing the immunosuppressive function of MDSCs in vivo and in vitro. Mechanistically, arctigenin promoted the accumulation of MDSCs through upregulating miR-127-5p which targets the 3'UTR of interferon regulatory factor-8 (IRF8) mRNA. In addition, arctigenin enhanced the immunosuppressive activity of MDSCs on M1 macrophage polarization by elevating the expression of arginase 1 (Arg-1) and inducible nitric oxide synthase (iNOS). Our study provides new insights into the regulation of functional MDSCs by arctigenin in exerting immune responses and pathogenesis of inflammatory diseases.Entities:
Keywords: Arg-1; IRF8; LPS; MDSCs; arctigenin; iNOS
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Year: 2018 PMID： 30143931 DOI： 10.1007/s10753-018-0852-1
Source DB: PubMed Journal: Inflammation ISSN： 0360-3997 Impact factor: 4.092