| Literature DB >> 30143819 |
Mailis Michaud Maturana1, Ismini Panayotidis1, Savvas Psarelis2,3, George Nakos4, Elena Nikiphorou5,6.
Abstract
Mesenteric panniculitis (MP) is a rare chronic disease characterized by inflammation and subsequently fibrosis of adipose tissue of the omentum. Only recently it has been associated with IgG4-related disease. Cancer antigen 125 (CA-125) is a high-molecular mass glycoprotein, traditionally associated with ovarian cancer, although it can be elevated in other conditions. Herein we describe a case of a 56-year-old man with IgG4 related mesenteric panniculitis associated with very high levels of CA-125 at the onset of disease. The CA-125 levels corresponded to clinical disease activity and improved with steroid therapy and rituximab. A literature review was performed concerning possible association of MP, IgG4-related disease and CA-125. The review of literature suggests that high levels of CA-125 can be raised in non-malignant, inflammatory conditions including IgG4-related mesenteritis and can improve with treatment.Entities:
Keywords: Biomarkers, tumor; CA-125 antigen; Immunoglobulin G; Inflammation; Mesentery; Panniculitis, peritoneal; Peritoneum
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Year: 2018 PMID： 30143819 DOI： 10.1007/s00296-018-4145-7
Source DB: PubMed Journal: Rheumatol Int ISSN： 0172-8172 Impact factor: 2.631