Literature DB >> 3014375

Effects of intracarotid ionic and non-ionic contrast material on the blood-brain barrier in a rabbit model.

J Wilcox, C A Evill, M R Sage.   

Abstract

A rabbit model was used to assess the effects of intracarotid injections of ionic monomer (meglumine iothalamate), non-ionic monomer (iohexol, iopromide), and non-ionic dimer (iotrol) contrast materials on the blood-brain barrier. The degree of blood-brain barrier damage was assessed qualitatively using Evans' blue dye, and quantitatively by calculating the difference in pertechnetate uptake between injected and non-injected hemispheres. The results showed that the non-ionic dimer, iotrol, had the least effect on the blood-brain barrier, and that although iopromide and iohexol produced greater damage than iotrol, the ionic compound, meglumine iothalamate, caused the greatest disruption to the blood-brain barrier. The implications of these findings are discussed.

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Year:  1986        PMID： 3014375     DOI： 10.1007/bf00548204

Source DB:  PubMed          Journal:  Neuroradiology        ISSN： 0028-3940            Impact factor:   2.804


  10 in total

Review 1.  The new low-osmolar contrast media: a simple guide.

Authors:  P Dawson; R G Grainger; J Pitfield
Journal:  Clin Radiol       Date:  1983-03       Impact factor: 2.350

2.  Iohexol.

Authors:  J Haavaldsen
Journal:  Acta Radiol Suppl       Date:  1980

3.  Is viscosity important in the production of blood-brain barrier disruption by intracarotid contrast media?

Authors:  J Wilcox; M R Sage
Journal:  Neuroradiology       Date:  1984       Impact factor: 2.804

4.  Comparison of blood-brain barrier disruption in the rabbit following intracarotid iopamidol and methylglucamine iothalamate.

Authors:  A G Wycherley; J Wilcox; M R Sage
Journal:  Australas Radiol       Date:  1984-11

5.  Comparison and evaluation of osmotic blood-brain barrier disruption following intracarotid mannitol and methylglucamine iothalamate.

Authors:  M R Sage; J Wilcox; C A Evill; G T Benness
Journal:  Invest Radiol       Date:  1982 May-Jun       Impact factor: 6.016

6.  Radiopaque contrast media. XLIV - Preclinical studies with a new nonionic contrast agent.

Authors:  E Felder; D Pitrè; P Tirone
Journal:  Farmaco Sci       Date:  1977-11

7.  Pharmacochemical profile of iopromide.

Authors:  W Muetzel; U Speck
Journal:  AJNR Am J Neuroradiol       Date:  1983 May-Jun       Impact factor: 3.825

8.  Osmolality of intravascular radiological contrast media.

Authors:  R G Grainger
Journal:  Br J Radiol       Date:  1980-08       Impact factor: 3.039

9.  Shortcomings of 99m Tc-pertechnetate as a tracer for brain tumor detection as shown by well counting of human brain tumors and a mouse ependymoblastoma.

Authors:  M L Schwartz; C H Tator
Journal:  J Nucl Med       Date:  1972-05       Impact factor: 10.057

10.  Nonionic dimer: development and initial testing of an intrathecal contrast agent.

Authors:  M Sovak; R Ranganathan; U Speck
Journal:  Radiology       Date:  1982-01       Impact factor: 11.105
  10 in total
  2 in total

Review 1.  Biliary Epithelial Senescence in Liver Disease: There Will Be SASP.

Authors:  Vik Meadows; Leonardo Baiocchi; Debjyoti Kundu; Keisaku Sato; Yessenia Fuentes; Chaodong Wu; Sanjukta Chakraborty; Shannon Glaser; Gianfranco Alpini; Lindsey Kennedy; Heather Francis
Journal:  Front Mol Biosci       Date:  2021-12-21

Review 2.  Is contrast medium osmolality a causal factor for contrast-induced nephropathy?

Authors:  Andreas M Bucher; Carlo N De Cecco; U Joseph Schoepf; Felix G Meinel; Aleksander W Krazinski; James V Spearman; Andrew D McQuiston; Rui Wang; Judith Bucher; Thomas J Vogl; Richard W Katzberg
Journal:  Biomed Res Int       Date:  2014-03-31       Impact factor: 3.411
  2 in total

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