Bairong Chen1, Liyun Luo1, Xiaoliang Wei1, Dong Gong1, Lizi Jin2. 1. Department of Cardiology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, China. 2. Department of Cardiology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, China jinliziscience@hotmail.com.
Abstract
BACKGROUND: MicroRNAs (miRNAs) have been found to be involved in coronary artery disease (CAD) and corresponding disease severity. The aim of this study is to determine plasma levels of miR-144 in CAD and its association with the severity of this disease. METHODS: Plasma levels of miR-144 in 60 CAD patients including stable angina pectoris (SAP) (n=29), unstable angina pectoris (UAP) or non-ST elevation myocardial infarction (MI) (NSTEMI) (n=17), or ST-elevation MI (STEMI) (n=14) and 20 non-CAD subjects were detected by real-time polymerase chain reaction (QRT-PCR). Associations of miR-144 expression with basic clinical characteristics and the severity of CAD were then analyzed. RESULTS: The QRT-PCR results showed that plasma miR-144 levels were increased in CAD patients, and among CAD patients, higher SYNTAX scores and STEMI were significantly associated with higher miR-144 expression. CONCLUSIONS: Higher plasma levels of miR-144 were significantly associated with the presence as well as severity of CAD. As a potential biomarker for CAD, plasma miR-144 may be useful in predicting CAD and its severity.
BACKGROUND: MicroRNAs (miRNAs) have been found to be involved in coronary artery disease (CAD) and corresponding disease severity. The aim of this study is to determine plasma levels of miR-144 in CAD and its association with the severity of this disease. METHODS: Plasma levels of miR-144 in 60 CAD patients including stable angina pectoris (SAP) (n=29), unstable angina pectoris (UAP) or non-ST elevation myocardial infarction (MI) (NSTEMI) (n=17), or ST-elevation MI (STEMI) (n=14) and 20 non-CAD subjects were detected by real-time polymerase chain reaction (QRT-PCR). Associations of miR-144 expression with basic clinical characteristics and the severity of CAD were then analyzed. RESULTS: The QRT-PCR results showed that plasma miR-144 levels were increased in CAD patients, and among CAD patients, higher SYNTAX scores and STEMI were significantly associated with higher miR-144 expression. CONCLUSIONS: Higher plasma levels of miR-144 were significantly associated with the presence as well as severity of CAD. As a potential biomarker for CAD, plasma miR-144 may be useful in predicting CAD and its severity.
Authors: Alexandra V Rozhkova; Veronika G Dmitrieva; Elena V Nosova; Alexander D Dergunov; Svetlana A Limborska; Liudmila V Dergunova Journal: J Cardiovasc Dev Dis Date: 2021-12-02
Authors: Daniel P Zalewski; Karol P Ruszel; Andrzej Stępniewski; Dariusz Gałkowski; Marcin Feldo; Janusz Kocki; Anna Bogucka-Kocka Journal: J Clin Med Date: 2022-03-15 Impact factor: 4.241