Marjan Asadollahi1, Mahyar Noorbakhsh2, Leila Simani3, Mahtab Ramezani4, Kurosh Gharagozli4. 1. Epilepsy Department, Loghman-Hakim Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: marjanasadollahi54@gmail.com. 2. Epilepsy Department, Loghman-Hakim Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: mahyar_noor@yahoo.com. 3. Skull Base Research Center, Loghman-Hakim Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. 4. Epilepsy Department, Loghman-Hakim Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
Abstract
PURPOSE: To determine the effect of different seizure characteristics on the occurrence of postictal generalized EEG suppression (PGES). PGES is considered as a potential risk factor of sudden unexpected death in epilepsy (SUDEP) by several studies. METHODS: In this retrospective cross-sectional study, episodes of generalized convulsive seizures (GCS) were reviewed in regard to state at seizure-onset, the seizure and tonic phase durations, postictal immobility (PI) duration and whether the patient received oxygen (O2) mask during the post-ictal phase. Moreover, the presence and duration of PGES was determined for each seizure. RESULTS: Among 98 episodes of GCSs, 56 (57.1%) had PGES and 42 (42.9%) did not have PGES. The mean seizure duration for attacks with and without PGES was 106.62 ± 97.04 and 104.85 ± 91.81 s, respectively (P > 0.05). The tonic phase duration was significantly longer in PGES positive compared to PGES negative seizures (4.25 ± 3.17 s vs. 2.82 ± 3.58 s, P < 0.05). Early O2 mask administration and state of wakefulness at seizure-onset did not show any significant correlation with the presence of PGES (P > 0.05). Seizures with PGES had higher PI duration than those without PGES (156.24 s vs. 124.73 s) (P < 0.05). Interestingly, in seizures with PGES, there was a positive correlation between PI and tonic phase durations (r: 0.4, P < 0.05). CONCLUSIONS: According to our findings, higher tonic phase duration and longer PI period increased the odds of PGES formation.
PURPOSE: To determine the effect of different seizure characteristics on the occurrence of postictal generalized EEG suppression (PGES). PGES is considered as a potential risk factor of sudden unexpected death in epilepsy (SUDEP) by several studies. METHODS: In this retrospective cross-sectional study, episodes of generalized convulsive seizures (GCS) were reviewed in regard to state at seizure-onset, the seizure and tonic phase durations, postictal immobility (PI) duration and whether the patient received oxygen (O2) mask during the post-ictal phase. Moreover, the presence and duration of PGES was determined for each seizure. RESULTS: Among 98 episodes of GCSs, 56 (57.1%) had PGES and 42 (42.9%) did not have PGES. The mean seizure duration for attacks with and without PGES was 106.62 ± 97.04 and 104.85 ± 91.81 s, respectively (P > 0.05). The tonic phase duration was significantly longer in PGES positive compared to PGES negative seizures (4.25 ± 3.17 s vs. 2.82 ± 3.58 s, P < 0.05). Early O2 mask administration and state of wakefulness at seizure-onset did not show any significant correlation with the presence of PGES (P > 0.05). Seizures with PGES had higher PI duration than those without PGES (156.24 s vs. 124.73 s) (P < 0.05). Interestingly, in seizures with PGES, there was a positive correlation between PI and tonic phase durations (r: 0.4, P < 0.05). CONCLUSIONS: According to our findings, higher tonic phase duration and longer PI period increased the odds of PGES formation.
Authors: Alexandra N Petrucci; Katelyn G Joyal; Jonathan W Chou; Rui Li; Kimberly M Vencer; Gordon F Buchanan Journal: Neuroscience Date: 2020-11-24 Impact factor: 3.590
Authors: Xiuhe Zhao; Laura Vilella; Liang Zhu; M R Sandhya Rani; Johnson P Hampson; Jaison Hampson; Norma J Hupp; Rup K Sainju; Daniel Friedman; Maromi Nei; Catherine Scott; Luke Allen; Brian K Gehlbach; Stephan Schuele; Ronald M Harper; Beate Diehl; Lisa M Bateman; Orrin Devinsky; George B Richerson; Guo-Qiang Zhang; Samden D Lhatoo; Nuria Lacuey Journal: Front Neurol Date: 2021-05-11 Impact factor: 4.003
Authors: Julia C M Pottkämper; Joey P A J Verdijk; Jeannette Hofmeijer; Jeroen A van Waarde; Michel J A M van Putten Journal: Epilepsia Open Date: 2021-08-20