| Literature DB >> 30142342 |
Paola Vagnarelli1, Dario R Alessi2.
Abstract
The identification of inhibitors targeting regulatory subunits of serine/threonine PP1 phosphatases reported by Krzyzosiak et al. is a significant step in expanding the pharmacological regulation of phosphorylation beyond kinases. The selective inhibitor of the R15B phosphatase regulatory subunit, termed Raphin1, protects cells from stress and delays neurodegeneration in a mouse model of Huntington's disease. CrownEntities:
Mesh：
Substances：
Year: 2018 PMID： 30142342 DOI： 10.1016/j.cell.2018.08.007
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582