Literature DB >> 30141796

Nucleophilic amination of methoxypyridines by a sodium hydride-iodide composite.

Jia Hao Pang1, Atsushi Kaga, Shunsuke Chiba.   

Abstract

A new protocol for nucleophilic amination of methoxypyridines and their derivatives was developed using sodium hydride (NaH) in the presence of lithium iodide (LiI). The method offers a concise access to various aminopyridines which are potentially of medicinal interest.

Entities:  

Year:  2018        PMID： 30141796     DOI： 10.1039/c8cc05979a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

Review 1.  Concerted Nucleophilic Aromatic Substitution Reactions.

Authors:  Simon Rohrbach; Andrew J Smith; Jia Hao Pang; Darren L Poole; Tell Tuttle; Shunsuke Chiba; John A Murphy
Journal:  Angew Chem Int Ed Engl       Date:  2019-09-13       Impact factor: 15.336

2.  Aggregation and Solvation of Sodium Hexamethyldisilazide: Across the Solvent Spectrum.

Authors:  Ryan A Woltornist; David B Collum
Journal:  J Org Chem       Date:  2021-01-20       Impact factor: 4.354

3.  Cation Radical-Accelerated Nucleophilic Aromatic Substitution for Amination of Alkoxyarenes.

Authors:  Nicholas J Venditto; David A Nicewicz
Journal:  Org Lett       Date:  2020-06-02       Impact factor: 6.005

4.  LiCl-promoted amination of β-methoxy amides (γ-lactones).

Authors:  Ru Zhao; Bing-Lin Zeng; Wen-Qiang Jia; Hong-Yi Zhao; Long-Ying Shen; Xiao-Jian Wang; Xian-Dao Pan
Journal:  RSC Adv       Date:  2020-09-21       Impact factor: 4.036
  4 in total

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