| Literature DB >> 30141635 |
Yang Da1, Shengnan Han1, Xiaoyong Du1, Shaodong Liu1, Lei Liu1, Jie Li1.
Abstract
An efficient copper(I)-catalyzed oxydifluoroalkylation of unsaturated carboxylic acids has been developed under mild reaction conditions. Various α-bromodifluoromethyl substituted heterocycles, esters, amides, and ketones were successfully employed as the CF2 source. This cost-effective copper(I) catalysis provides expedient access to high valued lactones with ample substrate scope, wide functional group tolerance, and up to 98% yield.Entities:
Year: 2018 PMID： 30141635 DOI： 10.1021/acs.orglett.8b02069
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005