Michael Darmon1,2,3, Julie Helms4,5, Audrey De Jong6,7, Peter Buhl Hjortrup8,9, Emmanuel Weiss10,11, Anders Granholm8, Riccardo Pinciroli12, Charlotte Poussardin4, Marie Warrer Petersen8, Stéphanie Sigaut9, Bruna Brandao Barreto6,13, Morten Hylander Moller8, Elie Azoulay6,10,14. 1. Medical ICU, Saint-Louis University Hospital, AP-HP, 1 Avenue Claude Vellefaux, 75010, Paris, France. michael.darmon@aphp.fr. 2. Faculté de Médecine, Université Paris-Diderot, Sorbonne-Paris-Cité, Paris, France. michael.darmon@aphp.fr. 3. ECSTRA team, Biostatistics and clinical epidemiology, UMR 1153 (center of epidemiology and biostatistic Sorbonne Paris Cité, CRESS), INSERM, Paris, France. michael.darmon@aphp.fr. 4. Faculté de Médecine, Hôpitaux universitaires de Strasbourg, Service de réanimation, Nouvel Hôpital Civil, Université de Strasbourg (UNISTRA), Strasbourg, France. 5. ImmunoRhumatologie Moléculaire, INSERM UMR_S1109, LabEx TRANSPLANTEX, Centre de Recherche d'Immunologie et d'Hématologie, Faculté de Médecine, Fédération Hospitalo-Universitaire (FHU) OMICARE, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Strasbourg, France. 6. Medical ICU, Saint-Louis University Hospital, AP-HP, 1 Avenue Claude Vellefaux, 75010, Paris, France. 7. PhyMedExp, INSERM, CNRS, CHU de Montpellier, Département d'anesthésie-réanimation Saint-Eloi, Université de Montpellier, 80, avenue Augustin-Fliche, 34295, Montpellier Cedex, France. 8. Department of Intensive Care, Copenhagen University Hospital-Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark. 9. Department of Anaesthesiology and Intensive Care, Zealand University Hospital, Lykkebækvej 1, 4600, Køge, Denmark. 10. Faculté de Médecine, Université Paris-Diderot, Sorbonne-Paris-Cité, Paris, France. 11. Department of Anesthesia and Critical Care, Beaujon University Hospital, AP-HP, Paris, France. 12. Department of Anesthesia and Critical Care, Niguarda Hospital, University of Milan-Bicocca, Milan, Italy. 13. Intensive Care Unit, Hospital da Mulher, Salvador, Brazil. 14. ECSTRA team, Biostatistics and clinical epidemiology, UMR 1153 (center of epidemiology and biostatistic Sorbonne Paris Cité, CRESS), INSERM, Paris, France.
Abstract
PURPOSE: Conflict of interest (COI) may compromise, or have the appearance of compromising, a researcher's judgment or integrity in conducting or reporting research. We sought to assess time trends of COI and funding statement reporting in the critical care literature. METHODS: PubMed was searched by using Medical Subject Headings and the appropriate corresponding keywords: "INTENSIVE CARE UNIT" or "ICU" as a major topic. Four years in a 15-year time period (2001-2016) were arbitrarily chosen and one study month was randomly selected for each study period. Studies published during the selected months were included in the analysis. RESULTS: Three hundred and seventy-four studies were evaluated, including five reviews (1.3%) and ten randomized clinical trials (RCTs) (2.7%). COI statements were available in 65% of the studies and 8% had declared COI. COI statement rate, declared COI and funding statements increased over time, while the number of authors affiliated with industry and the discordance between the lack of COI statement and affiliation with industry decreased. Declared COI were more frequent in 2011-2016 as compared to 2001-2010 (OR 4.06; 95% CI 1.15-25.79) and in the higher quartile of a journal's impact factor (OR of 16.73; 95% CI 3.28-306.20). Surprisingly, focus of the study, country of the first author and/or endorsement of the study by a trial group were not associated with COI statements. CONCLUSION: Our study suggests COI reporting to have been unintuitive to most investigators and unreliable before ICMJE statements, and that strong incentives are needed to implement adequate reporting of COI.
PURPOSE: Conflict of interest (COI) may compromise, or have the appearance of compromising, a researcher's judgment or integrity in conducting or reporting research. We sought to assess time trends of COI and funding statement reporting in the critical care literature. METHODS: PubMed was searched by using Medical Subject Headings and the appropriate corresponding keywords: "INTENSIVE CARE UNIT" or "ICU" as a major topic. Four years in a 15-year time period (2001-2016) were arbitrarily chosen and one study month was randomly selected for each study period. Studies published during the selected months were included in the analysis. RESULTS: Three hundred and seventy-four studies were evaluated, including five reviews (1.3%) and ten randomized clinical trials (RCTs) (2.7%). COI statements were available in 65% of the studies and 8% had declared COI. COI statement rate, declared COI and funding statements increased over time, while the number of authors affiliated with industry and the discordance between the lack of COI statement and affiliation with industry decreased. Declared COI were more frequent in 2011-2016 as compared to 2001-2010 (OR 4.06; 95% CI 1.15-25.79) and in the higher quartile of a journal's impact factor (OR of 16.73; 95% CI 3.28-306.20). Surprisingly, focus of the study, country of the first author and/or endorsement of the study by a trial group were not associated with COI statements. CONCLUSION: Our study suggests COI reporting to have been unintuitive to most investigators and unreliable before ICMJE statements, and that strong incentives are needed to implement adequate reporting of COI.
Entities:
Keywords:
Bias; Bibliometrics; Conflicts of interest; Disclosure/statistics and numerical data; Editorial policies; Journal impact factor; Periodicals as topic/standards
Authors: S V McCrary; C B Anderson; J Jakovljevic; T Khan; L B McCullough; N P Wray; B A Brody Journal: N Engl J Med Date: 2000-11-30 Impact factor: 91.245
Authors: Mina Bakhit; Mark Jones; Jenalle Baker; Ramil Nair; Kylie Yan; Chris Del Mar; Anna Mae Scott Journal: BMJ Open Date: 2021-07-20 Impact factor: 2.692