Literature DB >> 3014105

Treatment of murine coccidioidal meningitis with fluconazole (UK 49,858).

J R Graybill, S H Sun, J Ahrens.   

Abstract

Male ICR mice were challenged intracerebrally with endospores of Coccidioides immitis and then treated with water (control), fluconazole, amphotericin B (Fungizone), or ketoconazole (Nizoral). All three drugs markedly prolonged survival, and all three drugs lowered brain colony counts of C. immitis. Survival of mice treated orally with fluconazole at the high dose was longer than in the ketoconazole treated group. Amphotericin B was more efficacious than fluconazole. Further investigations are needed to determine the efficacy of fluconazole in treatment of coccidioidal meningitis.

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Year:  1986        PMID： 3014105     DOI： 10.1080/02681218680000171

Source DB:  PubMed          Journal:  J Med Vet Mycol        ISSN： 0268-1218


  18 in total

1.  Standardization of a fluconazole bioassay and correlation of results with those obtained by high-pressure liquid chromatography.

Authors:  J H Rex; L H Hanson; M A Amantea; D A Stevens; J E Bennett
Journal:  Antimicrob Agents Chemother       Date:  1991-05       Impact factor: 5.191

2.  In vitro and in vivo activities of Sch 39304, fluconazole, and amphotericin B against Histoplasma capsulatum.

Authors:  G S Kobayashi; S J Travis; M G Rinaldi; G Medoff
Journal:  Antimicrob Agents Chemother       Date:  1990-04       Impact factor: 5.191

Review 3.  Murine models of blastomycosis, coccidioidomycosis, and histoplasmosis.

Authors:  K N Sorensen; K V Clemons; D A Stevens
Journal:  Mycopathologia       Date:  1999       Impact factor: 2.574

4.  Comparison of SCH 39304 and its isomers, RR 42427 and SS 42426, for treatment of murine cryptococcal and coccidioidal meningitis.

Authors:  R Allendoerfer; R R Yates; A J Marquis; D Loebenberg; M G Rinaldi; J R Graybill
Journal:  Antimicrob Agents Chemother       Date:  1992-01       Impact factor: 5.191

Review 5.  Fluconazole. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in superficial and systemic mycoses.

Authors:  S M Grant; S P Clissold
Journal:  Drugs       Date:  1990-06       Impact factor: 9.546

6.  Coccidioidal meningitis acquired during holidays in Arizona.

Authors:  G D Taylor; D W Boettger; L J Miedzinski; D L Tyrrell
Journal:  CMAJ       Date:  1990-06-15       Impact factor: 8.262

7.  Comparison of itraconazole and fluconazole treatments in a murine model of coccidioidal meningitis.

Authors:  Perparim Kamberi; Raymond A Sobel; Karl V Clemons; Andreas Waldvogel; Joan M Striebel; Paul L Williams; David A Stevens
Journal:  Antimicrob Agents Chemother       Date:  2006-12-18       Impact factor: 5.191

8.  Microtiter method for MIC testing with spherule-endospore-phase Coccidioides immitis.

Authors:  R F Hector; B L Zimmer; D Pappagianis
Journal:  J Clin Microbiol       Date:  1988-12       Impact factor: 5.948

9.  Therapeutic effect of the triazole Bay R 3783 in mouse models of coccidioidomycosis, blastomycosis, and histoplasmosis.

Authors:  D Pappagianis; B L Zimmer; G Theodoropoulos; M Plempel; R F Hector
Journal:  Antimicrob Agents Chemother       Date:  1990-06       Impact factor: 5.191

10.  Efficacy of SCH39304 and fluconazole in a murine model of disseminated coccidioidomycosis.

Authors:  K V Clemons; L H Hanson; A M Perlman; D A Stevens
Journal:  Antimicrob Agents Chemother       Date:  1990-05       Impact factor: 5.191
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