Literature DB >> 30140517

Comparative Study of the Efficacy of Dexmedetomidine and Fentanyl as Adjuvants to Ropivacaine in Ultrasound-Guided Supraclavicular Brachial Plexus Block.

Pratibha Shivalgond Dharmarao1, Renuka Holyachi1.   

Abstract

OBJECTIVE: Supraclavicular brachial plexus block is preferable to general anaesthesia in upper limb surgeries. Various adjuvants have been added to improve the quality of the block and prolong postoperative analgesia. The aim of the present study was to compare the onset and duration of sensory and motor blockade with the quality of perioperative analgesia and postoperative complications provided by dexmedetomidine and fentanyl as adjuvants to ropivacaine under ultrasound (USG) guidance in supraclavicular block.
METHODS: A total of 80 patients with American Society of Anesthesiologists grade I/II scheduled for elective upper limb surgeries were randomly allocated into two groups. Group A received 30 mL of 0.5% ropivacaine with 1 μg kg-1 dexmedetomidine, and group B received 30 mL of 0.5% ropivacaine with 1 μg kg-1 fentanyl for supraclavicular brachial block using USG guidance. The onset and duration of sensory and motor block, time for requirement of rescue analgesia and adverse events during the perioperative period were noted.
RESULTS: The onset of sensory blockade was 13.95±1.34 min in the dexmedetomidine group and 14.18±1.41 min in the fentanyl group. There was a highly significant statistical difference in terms of the duration of the sensory blockade, i.e. 801.75±46.07 min with dexmedetomidine compared to 590.25±40.41 min with fentanyl (p<0.0001). The duration of motor blockade was highly statistically significant with 649.56±42.73 min in group A compared to 456.75±32.93 min in group B.
CONCLUSION: Dexmedetomidine prolongs the duration of sensory and motor block and postoperative analgesia as compared to fentanyl when used as an adjuvant to ropivacaine in supraclavicular brachial plexus block and is not associated with any major adverse events.

Entities:  

Keywords:  Ropivacaine; dexmedetomidine; fentanyl; supraclavicular brachial plexus block

Year:  2017        PMID: 30140517      PMCID: PMC6097859          DOI: 10.5152/TJAR.2018.98058

Source DB:  PubMed          Journal:  Turk J Anaesthesiol Reanim        ISSN: 2149-276X


  25 in total

1.  Posterior tibial nerve sensory blockade duration prolonged by adding dexmedetomidine to ropivacaine.

Authors:  Marie-Pier Malenfant Rancourt; Natalie T Albert; Maxime Côté; Dany-R Létourneau; Paul-Marie Bernard
Journal:  Anesth Analg       Date:  2012-07-23       Impact factor: 5.108

2.  Dexmedetomidine as an adjuvant to ropivacaine prolongs peripheral nerve block: a volunteer study.

Authors:  D Marhofer; S C Kettner; P Marhofer; S Pils; M Weber; M Zeitlinger
Journal:  Br J Anaesth       Date:  2012-11-15       Impact factor: 9.166

3.  Fentanyl improves analgesia but prolongs the onset of axillary brachial plexus block by peripheral mechanism.

Authors:  K Nishikawa; N Kanaya; M Nakayama; M Igarashi; K Tsunoda; A Namiki
Journal:  Anesth Analg       Date:  2000-08       Impact factor: 5.108

4.  Effect of clonidine as adjuvant in bupivacaine-induced supraclavicular brachial plexus block: A randomized controlled trial.

Authors:  Susmita Chakraborty; Jayanta Chakrabarti; Mohan Chandra Mandal; Avijit Hazra; Sabyasachi Das
Journal:  Indian J Pharmacol       Date:  2010-04       Impact factor: 1.200

5.  Dexmedetomidine enhances the local anesthetic action of lidocaine via an alpha-2A adrenoceptor.

Authors:  Tatsushi Yoshitomi; Atsushi Kohjitani; Shigeru Maeda; Hitoshi Higuchi; Masahiko Shimada; Takuya Miyawaki
Journal:  Anesth Analg       Date:  2008-07       Impact factor: 5.108

6.  A randomized controlled double-blinded prospective study of the efficacy of clonidine added to bupivacaine as compared with bupivacaine alone used in supraclavicular brachial plexus block for upper limb surgeries.

Authors:  Shivinder Singh; Amitabh Aggarwal
Journal:  Indian J Anaesth       Date:  2010-11

7.  Effect of addition of fentanyl to local anesthetic in brachial plexus block on duration of analgesia.

Authors:  Shirish G Chavan; Alka R Koshire; Prasad Panbude
Journal:  Anesth Essays Res       Date:  2011 Jan-Jun

8.  Effect of dexmedetomidine as adjuvant in ropivacaine-induced supraclavicular brachial plexus block: A prospective, double-blinded and randomized controlled study.

Authors:  Anjan Das; Saikat Majumdar; Susanta Halder; Surajit Chattopadhyay; Saswati Pal; Ratul Kundu; Subrata Kumar Mandal; Sandip Chattopadhyay
Journal:  Saudi J Anaesth       Date:  2014-11

9.  Efficacy of dexmedetomidine with ropivacaine in supraclavicular brachial plexus block for upper limb surgeries.

Authors:  Jithendra Chinnappa; Shivakumar Shivanna; Vinayak Seenappa Pujari; Tejesh Channasandra Anandaswamy
Journal:  J Anaesthesiol Clin Pharmacol       Date:  2017 Jan-Mar

10.  Dexmedetomidine prolongs the effect of bupivacaine in supraclavicular brachial plexus block.

Authors:  Sandhya Agarwal; Ritu Aggarwal; Praveen Gupta
Journal:  J Anaesthesiol Clin Pharmacol       Date:  2014-01
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