Literature DB >> 30140133

WNT16 induces proliferation and osteogenic differentiation of human perivascular stem cells.

Carolyn A Meyers1, Jia Shen2, Amy Lu1, Aaron W James1,2.   

Abstract

Perivascular stem cells (PSC) are a progenitor population defined by their perivascular residence. Recent studies have examined the relative difference in Wnt ligands to induce PSC differentiation, including Wnt16. Here, we examine the role of Wnt16 in the proliferation and osteogenic differentiation of human PSC. Treatment of PSC with WNT16 significantly increased cell proliferation to a greater extent than did WNT3A. In addition, WNT16 showed a significant increase in osteogenic gene expression among PSC. These data demonstrate that WNT16 represents a combined mitogenic/pro-osteogenic stimulus that may play a functional role in human mesenchymal stem cell mediated bone repair.

Entities:  

Keywords:  DKK1; Osteogenesis; PSC; Perivascular stem cell; WNT3A; Wnt signaling

Year:  2018        PMID： 30140133      PMCID： PMC6104460          DOI： 10.1016/j.jor.2018.08.021

Source DB:  PubMed          Journal:  J Orthop        ISSN： 0972-978X


  36 in total

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Authors:  Asal Askarinam; Aaron W James; Janette N Zara; Raghav Goyal; Mirko Corselli; Angel Pan; Pei Liang; Le Chang; Todd Rackohn; David Stoker; Xinli Zhang; Kang Ting; Bruno Péault; Chia Soo
Journal:  Tissue Eng Part A       Date:  2013-04-04       Impact factor: 3.845

8.  Effects of WNT3A and WNT16 on the Osteogenic and Adipogenic Differentiation of Perivascular Stem/Stromal Cells.

Authors:  Jia Shen; Xuepeng Chen; Haichao Jia; Carolyn A Meyers; Swati Shrestha; Greg Asatrian; Catherine Ding; Rebecca Tsuei; Xinli Zhang; Bruno Peault; Kang Ting; Chia Soo; Aaron W James
Journal:  Tissue Eng Part A       Date:  2017-05-22       Impact factor: 3.845

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Authors:  Aaron W James; Jia Shen; Xinli Zhang; Greg Asatrian; Raghav Goyal; Jin H Kwak; Lin Jiang; Benjamin Bengs; Cymbeline T Culiat; A Simon Turner; Howard B Seim Iii; Benjamin M Wu; Karen Lyons; John S Adams; Kang Ting; Chia Soo
Journal:  Nat Commun       Date:  2015-06-17       Impact factor: 14.919
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  2 in total

Review 1.  Perivascular Mesenchymal Progenitors for Bone Regeneration.

Authors:  Aaron W James; Bruno Péault
Journal:  J Orthop Res       Date:  2019-05-17       Impact factor: 3.494

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  2 in total

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