Aleksi Ruohomäki1, Elena Toffol2, Subina Upadhyaya3, Leea Keski-Nisula4, Juha Pekkanen5, Jussi Lampi6, Sari Voutilainen7, Tomi-Pekka Tuomainen7, Seppo Heinonen8, Kirsti Kumpulainen9, Markku Pasanen10, Soili M Lehto11. 1. Institute of Clinical Medicine / Psychiatry, University of Eastern Finland, Kuopio, Finland. Electronic address: aleksiru@student.uef.fi. 2. Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland. 3. Research Centre for Child Psychiatry, University of Turku, Turku, Finland. 4. Department of Obstetrics and Gynaecology, Kuopio University Hospital, Kuopio, Finland; Department of Health Sciences, Clinical Medicine, University of Eastern Finland, Kuopio, Finland. 5. Department of Health Protection, National Institute for Health and Welfare, Kuopio, Finland; Department of Public Health, University of Helsinki, Helsinki, Finland. 6. Department of Health Protection, National Institute for Health and Welfare, Kuopio, Finland; Social and Health, City of Kuopio, Kuopio, Finland. 7. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland. 8. Department of Obstetrics and Gynaecology, University of Helsinki, Helsinki, Finland; Department of Obstetrics and Gynaecology, Helsinki University Hospital, Helsinki, Finland. 9. Institute of Clinical Medicine / Child Psychiatry, University of Eastern Finland, Kuopio, Finland. 10. Faculty of Health Sciences, School of Pharmacy, University of Eastern Finland, Kuopio, Finland. 11. Institute of Clinical Medicine / Psychiatry, University of Eastern Finland, Kuopio, Finland; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Department of Psychiatry, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Department of Psychiatry, Kuopio University Hospital, Kuopio, Finland.
Abstract
BACKGROUND: The literature suggests an association between type 2 diabetes mellitus and depression, but data on the association between gestational diabetes mellitus (GDM) and postpartum depressive symptomatology (PPDS) are scarce. METHODS: Altogether, 1066 women with no previous mental health issues enrolled in the Kuopio Birth Cohort (KuBiCo, www.kubico.fi) were selected for this study. GDM was diagnosed according to the Finnish Current Care Guidelines. Depressive symptomatology was assessed with the Edinburgh Postnatal Depression Scale (EPDS) during the third trimester of pregnancy and eight weeks after delivery. Additionally, a subgroup of women (n = 505) also completed the EPDS during the first trimester of pregnancy. RESULTS: The prevalence rates of GDM and PPDS in the whole study population were 14.1% and 10.3%, respectively. GDM was associated with an increased likelihood of belonging to the PPDS group (OR 2.23, 95% CI 1.23-4.05; adjusted for maternal age at delivery, BMI in the first trimester, smoking before pregnancy, relationship status, nulliparity, delivery by caesarean section, gestational age at delivery, neonatal intensive care unit admission and third-trimester EPDS scores). A significant association between GDM and PPDS was found in the subgroup of women with available data on first-trimester depression (n = 505). LIMITATIONS: The participation rate of the KuBiCo study was relatively low (37%). CONCLUSIONS: Women with GDM may be at increased risk of PPDS. Future studies should investigate whether these women would benefit from a closer follow-up and possible supportive interventions during pregnancy and the postpartum period to avoid PPDS.
BACKGROUND: The literature suggests an association between type 2 diabetes mellitus and depression, but data on the association between gestational diabetes mellitus (GDM) and postpartum depressive symptomatology (PPDS) are scarce. METHODS: Altogether, 1066 women with no previous mental health issues enrolled in the Kuopio Birth Cohort (KuBiCo, www.kubico.fi) were selected for this study. GDM was diagnosed according to the Finnish Current Care Guidelines. Depressive symptomatology was assessed with the Edinburgh Postnatal Depression Scale (EPDS) during the third trimester of pregnancy and eight weeks after delivery. Additionally, a subgroup of women (n = 505) also completed the EPDS during the first trimester of pregnancy. RESULTS: The prevalence rates of GDM and PPDS in the whole study population were 14.1% and 10.3%, respectively. GDM was associated with an increased likelihood of belonging to the PPDS group (OR 2.23, 95% CI 1.23-4.05; adjusted for maternal age at delivery, BMI in the first trimester, smoking before pregnancy, relationship status, nulliparity, delivery by caesarean section, gestational age at delivery, neonatal intensive care unit admission and third-trimester EPDS scores). A significant association between GDM and PPDS was found in the subgroup of women with available data on first-trimester depression (n = 505). LIMITATIONS: The participation rate of the KuBiCo study was relatively low (37%). CONCLUSIONS:Women with GDM may be at increased risk of PPDS. Future studies should investigate whether these women would benefit from a closer follow-up and possible supportive interventions during pregnancy and the postpartum period to avoid PPDS.
Authors: Jerry Guintivano; Karolina A Aberg; Shaunna L Clark; David R Rubinow; Patrick F Sullivan; Samantha Meltzer-Brody; Edwin J C G van den Oord Journal: Mol Psychiatry Date: 2022-04-01 Impact factor: 13.437
Authors: E D John Eastwood; Andy Wang; Sarah Khanlari; Alicia Montgomery; Jean Yee Hwa Yang Journal: BMC Pregnancy Childbirth Date: 2021-04-06 Impact factor: 3.007