Cheri A Levinson1, Stephanie C Zerwas2, Leigh C Brosof1, Laura M Thornton2, Michael Strober3, Bernadette Pivarunas4, James J Crowley5, Zeynep Yilmaz2, Wade H Berrettini6, Harry Brandt7, Steven Crawford7, Manfred M Fichter8, Katherine A Halmi9, Craig Johnson10, Allan S Kaplan11, Maria La Via2, James Mitchell12, Alessandro Rotondo13, D Blake Woodside14, Walter H Kaye15, Cynthia M Bulik2,16,17. 1. Department of Psychological and Brain Sciences, University of Louisville, Louisville, Kentucky. 2. Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. 3. UCLA Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California. 4. Department of Psychology, Colorado State University, Fort Collins, Colorado. 5. Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. 6. Center of Neurobiology and Behavior, University of Pennsylvania, Philadelphia, Pennsylvania. 7. Center for Eating Disorders, Sheppard Pratt Health System, Towson, Maryland. 8. Klinik Roseneck, Hospital for Behavioral Medicine and University of Munich (LMU), Munich, Germany. 9. Weill Cornell Medical College, New York Presbyterian Hospital - Westchester Division, White Plains, New York. 10. Eating Recovery Center, Denver, Colorado. 11. Program for Eating Disorders, Toronto General Hospital and University Health Network, University of Toronto, Toronto, ON, Canada. 12. Department of Clinical Neuroscience and Neuropsychiatric Research Institute, University of North Dakota School of Medicine and Health Sciences, Fargo, North Dakota. 13. Department of Psychiatry, Pharmacology and Biotechnologies, University of Pisa, Pisa, Italy. 14. Department of Psychiatry, University of Toronto, Toronto, ON, Canada. 15. University of San Diego, San Diego, California. 16. Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. 17. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Abstract
OBJECTIVE: Anorexia nervosa (AN) and obsessive-compulsive disorder (OCD) are highly comorbid. However, the factors that account for this comorbidity are poorly understood. We examined the core dimensions of AN and OCD and psychological and personality factors shared by both disorders. METHOD: In path analyses (N = 732 women with either current AN or recovered from AN), we examined which factors were uniquely and independently associated with the core dimensions of AN and OCD. We also examined recovery from AN as a moderator. RESULTS: When individuals with AN reported greater concern over mistakes, they endorsed more severity in both AN and OCD core dimensions. These unique associations existed above and beyond all other transdiagnostic personality and psychological factors and regardless of AN recovery status. CONCLUSIONS: Concern over mistakes partially accounts for severity in the core dimensions of both AN and OCD. Concern over mistakes may represent an important target in the aetiology of AN and OCD.
OBJECTIVE:Anorexia nervosa (AN) and obsessive-compulsive disorder (OCD) are highly comorbid. However, the factors that account for this comorbidity are poorly understood. We examined the core dimensions of AN and OCD and psychological and personality factors shared by both disorders. METHOD: In path analyses (N = 732 women with either current AN or recovered from AN), we examined which factors were uniquely and independently associated with the core dimensions of AN and OCD. We also examined recovery from AN as a moderator. RESULTS: When individuals with AN reported greater concern over mistakes, they endorsed more severity in both AN and OCD core dimensions. These unique associations existed above and beyond all other transdiagnostic personality and psychological factors and regardless of AN recovery status. CONCLUSIONS: Concern over mistakes partially accounts for severity in the core dimensions of both AN and OCD. Concern over mistakes may represent an important target in the aetiology of AN and OCD.
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