| Literature DB >> 30135325 |
Le Thi Vien1,2, Tran Thi Hong Hanh1, Phan Thi Thanh Huong1, Nguyen Hai Dang1, Nguyen Van Thanh1, Nguyen Xuan Cuong1,2, Nguyen Hoai Nam1, Do Cong Thung3, Phan Van Kiem1, Chau Van Minh1.
Abstract
Seven anthraquinones including two new compounds namely capillasterquinones A and B (1 and 2) and one new butenolide namely capillasterolide (8) were isolated and structurally elucidated from the crinoid Capillaster multiradiatus. The inhibitory effect of compounds 1-8 on lipopolysaccharide (LPS)-induced nitric oxide (NO) production as well as inhibition of 1 on expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) proteins in RAW264.7 cells were also evaluated. As the obtained results, capillasterquinone A (1) showed strong NO production inhibitory activity with an IC50 of 5.89±0.11 µM. In addition, compound 1 reduced the LPS-induced iNOS and COX-2 expressions in a dose-dependent manner.Entities:
Keywords: Capillaster multiradiatus; anthraquinone; crinoid; cyclooxygenase 2 (COX-2); inducible nitric oxide synthase (iNOS); nitric oxide (NO) production
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Year: 2018 PMID： 30135325 DOI： 10.1248/cpb.c18-00472
Source DB: PubMed Journal: Chem Pharm Bull (Tokyo) ISSN： 0009-2363 Impact factor: 1.645