Alberto Benussi1, Valentina Dell'Era1, Valentina Cantoni1, Elisa Bonetta1, Roberto Grasso1, Rosa Manenti1, Maria Cotelli1, Alessandro Padovani1, Barbara Borroni2. 1. From the Neurology Unit (A.B., V.D., V.C., E.B., R.G., A.P., B.B.), Department of Clinical and Experimental Sciences, University of Brescia; Department of Neuroscience, Psychology, Drug Research and Child Health (V.C.), University of Florence; and Neuropsychology Unit (R.M., M.C.), IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy. 2. From the Neurology Unit (A.B., V.D., V.C., E.B., R.G., A.P., B.B.), Department of Clinical and Experimental Sciences, University of Brescia; Department of Neuroscience, Psychology, Drug Research and Child Health (V.C.), University of Florence; and Neuropsychology Unit (R.M., M.C.), IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy. bborroni@inwind.it.
Abstract
OBJECTIVE: To investigate whether a 2-week treatment with cerebellar anodal and spinal cathodal transcranial direct current stimulation (tDCS) could reduce symptoms in patients with neurodegenerative ataxia and could modulate cerebello-motor connectivity at the short and long terms. METHODS: We performed a double-blind, randomized, sham-controlled, crossover trial with cerebello-spinal tDCS (5 d/wk for 2 weeks) in 20 patients with neurodegenerative ataxia. Each patient underwent a clinical evaluation before and after real tDCS or sham stimulation. A follow-up evaluation was performed at 1 and 3 months with a crossover washout period of 3 months. Cerebello-motor connectivity was evaluated with transcranial magnetic stimulation at baseline and at each follow-up. RESULTS:Cerebello-spinal tDCS showed a significant improvement in all performance scores (Scale for the Assessment and Rating of Ataxia, International Cooperative Ataxia Rating Scale, 9-Hole Peg Test, 8-m walking time), in motor cortex excitability, and in cerebellar brain inhibition compared to sham stimulation. CONCLUSIONS: A 2-week treatment with cerebello-spinal tDCS reduces symptoms in patients with ataxia and restores motor cortex inhibition exerted by cerebellar structures. Cerebello-spinal tDCS might represent a promising future therapeutic and rehabilitative approach in patients with neurodegenerative ataxia, still an orphan disorder of any pharmacologic intervention. CLINICAL TRIAL REGISTRATION: NCT03120013. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that cerebello-spinal stimulation is effective and safe in cerebellar ataxia.
RCT Entities:
OBJECTIVE: To investigate whether a 2-week treatment with cerebellar anodal and spinal cathodal transcranial direct current stimulation (tDCS) could reduce symptoms in patients with neurodegenerative ataxia and could modulate cerebello-motor connectivity at the short and long terms. METHODS: We performed a double-blind, randomized, sham-controlled, crossover trial with cerebello-spinal tDCS (5 d/wk for 2 weeks) in 20 patients with neurodegenerative ataxia. Each patient underwent a clinical evaluation before and after real tDCS or sham stimulation. A follow-up evaluation was performed at 1 and 3 months with a crossover washout period of 3 months. Cerebello-motor connectivity was evaluated with transcranial magnetic stimulation at baseline and at each follow-up. RESULTS: Cerebello-spinal tDCS showed a significant improvement in all performance scores (Scale for the Assessment and Rating of Ataxia, International Cooperative Ataxia Rating Scale, 9-Hole Peg Test, 8-m walking time), in motor cortex excitability, and in cerebellar brain inhibition compared to sham stimulation. CONCLUSIONS: A 2-week treatment with cerebello-spinal tDCS reduces symptoms in patients with ataxia and restores motor cortex inhibition exerted by cerebellar structures. Cerebello-spinal tDCS might represent a promising future therapeutic and rehabilitative approach in patients with neurodegenerative ataxia, still an orphan disorder of any pharmacologic intervention. CLINICAL TRIAL REGISTRATION: NCT03120013. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that cerebello-spinal stimulation is effective and safe in cerebellar ataxia.
Authors: Roderick P P W M Maas; Ivan Toni; Jonne Doorduin; Thomas Klockgether; Dennis J L G Schutter; Bart P C van de Warrenburg Journal: BMC Neurol Date: 2019-07-04 Impact factor: 2.474
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