Stefania Chetcuti Zammit1, Pierre Ellul1, Giulia Girardin2, Daniela Valpiani3, Kári R Nielsen4, Jóngerð Olsen4, Adrian Goldis5, Daniela Lazar5, Olga Shonová6, Marie Nováková6, Shaji Sebastian7, Emma Whitehead7, Amalia Carmona8, Jesus Martinez-Cadilla9, Jens F Dahlerup10, Adriana L H Kievit11, Niels Thorsgaard11, Konstantinos H Katsanos12, Dimitrios K Christodoulou12, Fernando Magro13,14, Riina Salupere15, Natalia Pedersen16, Jens Kjeldsen17, Katrine Carlsen18, Kaimaklioti Ioannis19, Daniel Bergemalm20, Jonas Halfvarson20, Dana Duricova21, Martin Bortlik21, Pekka Collin22, Pia Oksanen22, Gediminas Kiudelis23, Limas Kupcinskas23, Karen Kudsk24, Vibeke Andersen25, Colm O'Morain26, Yvonne Bailey26, Schwartz Doron27, Odes Shmuel27, Sven Almer28,29, Naila Arebi30, Ravi Misra30, Silvija Čuković-Čavka31, Marko Brinar31, Pia Munkholm32, Zsuzsanna Vegh33, Johan Burisch32. 1. Gastroenterology Division, Mater Dei Hospital, Malta. 2. Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, Padua. 3. U.O. Gastroenterologia ed Endoscopia Digestiva, Ospedale Morgagni, Pierantoni, Forlì, Italy. 4. Medical Department, The National Hospital of the Faroe Islands, Torshavn, Faroe Islands. 5. Clinic of Gastroenterology, University of Medicine 'Victor Babes', Timisoara, Romania, Balkans. 6. Hospital Budweis, South Bohemia. 7. IBD Unit, Hull and East Yorkshire NHS Trust. 8. Department of Gastroenterology, Hospital Povisa, Vigo. 9. Department of Gastroenterology, Instituto de Investigación Biomédica Galicia Sur. Estrutura Organizativa de Xestión Integrada de Vigo, Spain. 10. Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus. 11. Herning. 12. Division of Gastroenterology, Medical School and University Hospital of Ioannina, Greece. 13. Gastroenterology Department, Hospital São João. 14. Institute of Pharmacology and Therapeutics Faculty of Medicine of the University of Porto, Porto, Portugal. 15. Tartu University Hospital, University of Tartu, Tartu, Estonia. 16. Gastroenterology Department Slagelse Hospital, Slagelse. 17. Gastroenterology Department, Odense University Hospital, Odense C. 18. Department of Pediatrics, Hvidovre Hospital, University of Copenhagen, Hvidovre. 19. Nicosia Private Practice, Cyprus. 20. Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro. 21. IBD Clinical and Research Centre Iscare, Prague, Czech Republic. 22. Pekka Collin Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland. 23. Department of Gastroenterology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania. 24. Medical Department, Viborg Regional Hospital, Viborg. 25. Focused Research Unit for Molecular Diagnostic and Clinical Research, IRS-Center Sonderjylland, Hospital of Southern Jutland, Aabenraa. 26. Department of Gastroenterology, Adelaide and Meath Hospital, TCD, Dublin, Ireland. 27. Department of Gastroenterology and Hepatology, Soroka Medical Centre, Ben-Gurion University of the Negev, Faculty of Health Sciences, Beer-Sheva, Israel. 28. Department of Medicine, Solna, Karolinska Institutet. 29. Center for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden. 30. IBD Department St Mark's Hospital, London, UK. 31. University Hospital Center Zagreb, School of Medicine University of Zagreb, Zagreb, Croatia. 32. Department of Gastroenterology, North Zealand University Hospital, Roskilde, Denmark. 33. Semmelweis University, Budapest, Hungary.
Abstract
BACKGROUND: Serum vitamin D level is commonly low in patients with inflammatory bowel disease (IBD). Although there is a growing body of evidence that links low vitamin D level to certain aspects of IBD such as disease activity and quality of life, data on its prevalence and how it varies across disease phenotype, smoking status and treatment groups are still missing. MATERIALS AND METHODS: Patients diagnosed with IBD between 2010 and 2011 were recruited. Demographic data and serum vitamin D levels were collected. Variance of vitamin D level was then assessed across different treatment groups, disease phenotype, disease activity and quality of life scores. RESULTS: A total of 238 (55.9% male) patients were included. Overall, 79% of the patients had either insufficient or deficient levels of vitamin D at diagnosis. Patients needing corticosteroid treatment at 1 year had significantly lower vitamin D levels at diagnosis (median 36.0 nmol/l) (P=0.035). Harvey-Bradshaw Index (P=0.0001) and Simple Clinical Colitis Activity Index scores (P=0.0001) were significantly lower in patients with higher vitamin D level. Serum vitamin D level correlated significantly with SIBQ score (P=0.0001) and with multiple components of SF12. Smokers at diagnosis had the lowest vitamin D levels (vitamin D: 34 nmol/l; P=0.053). CONCLUSION: This study demonstrates the high prevalence of low vitamin D levels in treatment-naive European IBD populations. Furthermore, it demonstrates the presence of low vitamin D levels in patients with IBD who smoke.
BACKGROUND: Serum vitamin D level is commonly low in patients with inflammatory bowel disease (IBD). Although there is a growing body of evidence that links low vitamin D level to certain aspects of IBD such as disease activity and quality of life, data on its prevalence and how it varies across disease phenotype, smoking status and treatment groups are still missing. MATERIALS AND METHODS:Patients diagnosed with IBD between 2010 and 2011 were recruited. Demographic data and serum vitamin D levels were collected. Variance of vitamin D level was then assessed across different treatment groups, disease phenotype, disease activity and quality of life scores. RESULTS: A total of 238 (55.9% male) patients were included. Overall, 79% of the patients had either insufficient or deficient levels of vitamin D at diagnosis. Patients needing corticosteroid treatment at 1 year had significantly lower vitamin D levels at diagnosis (median 36.0 nmol/l) (P=0.035). Harvey-Bradshaw Index (P=0.0001) and Simple Clinical Colitis Activity Index scores (P=0.0001) were significantly lower in patients with higher vitamin D level. Serum vitamin D level correlated significantly with SIBQ score (P=0.0001) and with multiple components of SF12. Smokers at diagnosis had the lowest vitamin D levels (vitamin D: 34 nmol/l; P=0.053). CONCLUSION: This study demonstrates the high prevalence of low vitamin D levels in treatment-naive European IBD populations. Furthermore, it demonstrates the presence of low vitamin D levels in patients with IBD who smoke.
Authors: Viktor Domislović; Darija Vranešić Bender; Ana Barišić; Marko Brinar; Dina Ljubas Kelečić; Cecilija Rotim; Martin Novosel; Marija Matašin; Željko Krznarić Journal: Acta Clin Croat Date: 2020-03 Impact factor: 0.780
Authors: T Hammer; S Nymand Lophaven; K Rubek Nielsen; M Skaalum Petersen; P Munkholm; P Weihe; J Burisch; E Lynge Journal: United European Gastroenterol J Date: 2019-05-19 Impact factor: 4.623