Natalie J Collins1, Edwin H G Oei2, Janneke L de Kanter3, Bill Vicenzino4, Kay M Crossley5. 1. University of Queensland, Brisbane, Queensland, and University of Melbourne and La Trobe University, Melbourne, Victoria, Australia. 2. Erasmus MC Rotterdam, Rotterdam, The Netherlands. 3. Erasmus MC Rotterdam, Rotterdam, and Rijnstate Hospital, Arnhem, The Netherlands. 4. University of Queensland, Brisbane, Queensland, Australia. 5. La Trobe University, Melbourne, Victoria, Australia.
Abstract
OBJECTIVE: To describe the prevalence of radiographic features of patellofemoral (PF) osteoarthritis (OA) in adults with persistent PF pain, to describe the prevalence of magnetic resonance imaging (MRI)-defined PF OA and compare it to that in age- and sex-matched controls, and to explore the prevalence of radiographic and MRI-defined PF OA across age, sex, and body mass index (BMI) groups. METHODS: This cross-sectional study included 84 individuals with PF pain ≥3 months duration and 26 age- and sex-matched controls. In participants with PF pain, posteroanterior, lateral, and skyline radiographs were obtained. Radiographic OA features were scored using Kellgren/Lawrence (K/L) criteria and a radiographic atlas, with K/L grade ≥2 defined as OA, and K/L grade 1 as early OA. Both groups underwent 3.0 Tesla MRI scans, scored using the MRI Osteoarthritis Knee Score criteria. Compartmental prevalence of MRI OA features was based on cartilage lesions, bone marrow lesions (BMLs), and osteophytes. RESULTS: Overall, 20 participants (24%) with PF pain had radiographic PF OA (K/L grade ≥2), and 36 participants (43%) had early PF OA (K/L grade 1). MRI-defined PF OA was more prevalent in participants with PF pain (16-29%) than in controls (4-12%), irrespective of how PF OA was defined. Within the PF pain group, the prevalence of PF OA on radiographs and MRI was greater in participants who were older or female or who had a higher BMI. CONCLUSION: Features of radiographic and MRI-defined PF OA were evident in 20-30% of adults ages 26-50 years with persistent PF pain, with greater prevalence observed in those who were older, or female, or who had a higher BMI. MRI-defined PF OA was more prevalent in individuals with PF pain than in pain-free controls, especially when defined as a full-thickness cartilage lesion with BML.
OBJECTIVE: To describe the prevalence of radiographic features of patellofemoral (PF) osteoarthritis (OA) in adults with persistent PF pain, to describe the prevalence of magnetic resonance imaging (MRI)-defined PF OA and compare it to that in age- and sex-matched controls, and to explore the prevalence of radiographic and MRI-defined PF OA across age, sex, and body mass index (BMI) groups. METHODS: This cross-sectional study included 84 individuals with PF pain ≥3 months duration and 26 age- and sex-matched controls. In participants with PF pain, posteroanterior, lateral, and skyline radiographs were obtained. Radiographic OA features were scored using Kellgren/Lawrence (K/L) criteria and a radiographic atlas, with K/L grade ≥2 defined as OA, and K/L grade 1 as early OA. Both groups underwent 3.0 Tesla MRI scans, scored using the MRI Osteoarthritis Knee Score criteria. Compartmental prevalence of MRI OA features was based on cartilage lesions, bone marrow lesions (BMLs), and osteophytes. RESULTS: Overall, 20 participants (24%) with PF pain had radiographic PF OA (K/L grade ≥2), and 36 participants (43%) had early PF OA (K/L grade 1). MRI-defined PF OA was more prevalent in participants with PF pain (16-29%) than in controls (4-12%), irrespective of how PF OA was defined. Within the PF pain group, the prevalence of PF OA on radiographs and MRI was greater in participants who were older or female or who had a higher BMI. CONCLUSION: Features of radiographic and MRI-defined PF OA were evident in 20-30% of adults ages 26-50 years with persistent PF pain, with greater prevalence observed in those who were older, or female, or who had a higher BMI. MRI-defined PF OA was more prevalent in individuals with PF pain than in pain-free controls, especially when defined as a full-thickness cartilage lesion with BML.
Authors: Natalie J Collins; Tuhina Neogi; Bill Vicenzino; Ali Guermazi; Frank W Roemer; Cora E Lewis; James C Torner; Michael C Nevitt; Joshua J Stefanik Journal: J Rheumatol Date: 2020-03-01 Impact factor: 4.666
Authors: Erika K Zambarano; David M Bazett-Jones; Danilo de Oliveira Silva; Christian J Barton; Neal R Glaviano Journal: J Athl Train Date: 2022-01-01 Impact factor: 2.860
Authors: Harvi F Hart; Tuhina Neogi; Michael LaValley; Daniel White; Yuqing Zhang; Michael C Nevitt; James Torner; Cora E Lewis; Joshua J Stefanik Journal: J Rheumatol Date: 2021-09-01 Impact factor: 4.666
Authors: Marienke van Middelkoop; Erin M Macri; Joost F Eijkenboom; Rianne A van der Heijden; Kay M Crossley; Sita M A Bierma-Zeinstra; Janneke L de Kanter; Edwin H Oei; Natalie J Collins Journal: Am J Sports Med Date: 2018-10-15 Impact factor: 6.202
Authors: Erin M Macri; Tuhina Neogi; Mohamed Jarraya; Ali Guermazi; Frank Roemer; Cora E Lewis; James C Torner; John A Lynch; Irina Tolstykh; S Reza Jafarzadeh; Joshua J Stefanik Journal: Arthritis Care Res (Hoboken) Date: 2022-06-08 Impact factor: 5.178
Authors: Jade M Tan; Kay M Crossley; Shannon E Munteanu; Natalie J Collins; Harvi F Hart; Joel W Donnar; Gearoid Cleary; Isobel C O'Sullivan; Liam R Maclachlan; Catherine L Derham; Hylton B Menz Journal: J Foot Ankle Res Date: 2020-09-23 Impact factor: 2.303