Kamil E Barbour1, Naoko Sagawa2, Robert M Boudreau2, Mary E Winger2, Jane A Cauley2, Michael C Nevitt3, Tomoko Fujii4, Kushang V Patel5, Elsa S Strotmeyer2. 1. Centers for Disease Control and Prevention, Atlanta, Georgia, and United States Public Health Service, Commissioned Corps, Rockville, Maryland. 2. University of Pittsburgh, Pittsburgh, Pennsylvania. 3. University of California, San Francisco. 4. University of Pittsburgh, Pittsburgh, Pennsylvania, and The University of Tokyo Hospital, Tokyo, Japan. 5. University of Washington, Seattle.
Abstract
OBJECTIVE: The risk of falls among adults with knee osteoarthritis (OA) has been documented, yet, to our knowledge no studies have examined knee OA and the risk of medically treated injurious falls (overall and by sex), which is an outcome of substantial clinical and public health relevance. METHODS: Using data from the Health Aging and Body Composition Knee Osteoarthritis Substudy, a community-based study of white and African American older adults, we tested associations between knee OA status and the risk of injurious falls among 734 participants with a mean ± SD age of 74.7 ± 2.9 years. Knee radiographic OA (ROA) was defined as having a Kellgren-Lawrence grade of ≥2 in at least 1 knee. Knee symptomatic ROA (sROA) was defined as having both ROA and pain symptoms in the same knee. Injurious falls were defined using a validated diagnosis code algorithm from linked Medicare fee-for-service claims. Cox regression modeling was used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs). RESULTS: The mean ± SD follow-up time was 6.59 ± 3.12 years. Of the 734 participants, 255 (34.7%) had an incident injurious fall over the entire study period. In the multivariate model, compared with those without ROA or pain, individuals with sROA (HR 1.09 [95% CI 0.73-1.65]) did not have a significantly increased risk of injurious falls. Compared with men without ROA or pain, men with sROA (HR 2.57 [95% CI 1.12-5.91]) had a significantly higher risk of injurious falls. No associations were found for women or by injurious fall type. CONCLUSION: Knee sROA was independently associated with an increased risk of injurious falls in older men, but not in older women.
OBJECTIVE: The risk of falls among adults with knee osteoarthritis (OA) has been documented, yet, to our knowledge no studies have examined knee OA and the risk of medically treated injurious falls (overall and by sex), which is an outcome of substantial clinical and public health relevance. METHODS: Using data from the Health Aging and Body Composition Knee Osteoarthritis Substudy, a community-based study of white and African American older adults, we tested associations between knee OA status and the risk of injurious falls among 734 participants with a mean ± SD age of 74.7 ± 2.9 years. Knee radiographic OA (ROA) was defined as having a Kellgren-Lawrence grade of ≥2 in at least 1 knee. Knee symptomatic ROA (sROA) was defined as having both ROA and pain symptoms in the same knee. Injurious falls were defined using a validated diagnosis code algorithm from linked Medicare fee-for-service claims. Cox regression modeling was used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs). RESULTS: The mean ± SD follow-up time was 6.59 ± 3.12 years. Of the 734 participants, 255 (34.7%) had an incident injurious fall over the entire study period. In the multivariate model, compared with those without ROA or pain, individuals with sROA (HR 1.09 [95% CI 0.73-1.65]) did not have a significantly increased risk of injurious falls. Compared with men without ROA or pain, men with sROA (HR 2.57 [95% CI 1.12-5.91]) had a significantly higher risk of injurious falls. No associations were found for women or by injurious fall type. CONCLUSION: Knee sROA was independently associated with an increased risk of injurious falls in older men, but not in older women.
Authors: Adam L Doré; Yvonne M Golightly; Vicki S Mercer; Xiaoyan A Shi; Jordan B Renner; Joanne M Jordan; Amanda E Nelson Journal: Arthritis Care Res (Hoboken) Date: 2015-05 Impact factor: 4.794
Authors: Michael C Nevitt; Irina Tolstykh; Najia Shakoor; Uyen-Sa D T Nguyen; Neil A Segal; Cora Lewis; David T Felson Journal: Arthritis Care Res (Hoboken) Date: 2016-08 Impact factor: 4.794
Authors: S R Cummings; M C Nevitt; W S Browner; K Stone; K M Fox; K E Ensrud; J Cauley; D Black; T M Vogt Journal: N Engl J Med Date: 1995-03-23 Impact factor: 91.245
Authors: Kamil E Barbour; Judy A Stevens; Charles G Helmick; Yao-Hua Luo; Louise B Murphy; Jennifer M Hootman; Kristina Theis; Lynda A Anderson; Nancy A Baker; David E Sugerman Journal: MMWR Morb Mortal Wkly Rep Date: 2014-05-02 Impact factor: 17.586
Authors: Mikael Anne Greenwood-Hickman; Dori E Rosenberg; Elizabeth A Phelan; Annette L Fitzpatrick Journal: Prev Chronic Dis Date: 2015-06-11 Impact factor: 2.830
Authors: N M van Schoor; E Dennison; M V Castell; C Cooper; M H Edwards; S Maggi; N L Pedersen; S van der Pas; J J M Rijnhart; P Lips; D J H Deeg Journal: Semin Arthritis Rheum Date: 2020-02-19 Impact factor: 5.532