Fanfan Zheng1, Baoliang Zhong2, Xiaoyu Song3, Wuxiang Xie4. 1. Associate Research Fellow,Brainnetome Center Institute of Automation,Chinese Academy of Sciences,China and Visiting Research Fellow,Institute of Cognitive Neuroscience,University College London,UK. 2. Associate Professor,Department of Geriatric Psychiatry,Affiliated Wuhan Mental Health Center,Tongji Medical College of Huazhong University of Science & Technology,China. 3. Assistant Professor,Department of Population Health Science and Policy,Icahn School of Medicine at Mount Sinai,USA. 4. Associate Research Fellow,Peking University Clinical Research Institute, Peking University Health Science Center,China and Newton International Fellow,Department of Epidemiology and Biostatistics,School of Public Health,Imperial College London,UK.
Abstract
BACKGROUND: Little is known about the effect of persistent depressive symptoms on the trajectory of cognitive decline.AimsWe aimed to investigate the longitudinal association between the duration of depressive symptoms and subsequent cognitive decline over a 10-year follow-up period. METHOD: The English Longitudinal Study of Ageing cohort is a prospective and nationally representative cohort of men and women living in England aged ≥50 years. We examined 7610 participants with two assessments of depressive symptoms at wave 1 (2002-2003) and wave 2 (2004-2005), cognitive data at wave 2 and at least one reassessment of cognitive function (wave 3 to wave 7, 2006-2007 to 2014-2015). RESULTS: The mean age of the 7610 participants was 65.2 ± 10.1 years, and 57.0% were women. Of these, 1157 (15.2%) participants had episodic depressive symptoms and 525 participants (6.9%) had persistent depressive symptoms. Compared with participants without depressive symptoms at wave 1 and wave 2, the multivariable-adjusted rates of global cognitive decline associated with episodic depressive symptoms and persistent depressive symptoms were faster by -0.065 points/year (95% CI -0.129 to -0.000) and -0.141 points/year (95% CI -0.236 to -0.046), respectively (P for trend < 0.001). Similarly, memory, executive and orientation function also declined faster with increasing duration of depressive symptoms (all P for trend < 0.05). CONCLUSIONS: Our results demonstrated that depressive symptoms were significantly associated with subsequent cognitive decline over a 10-year follow-up period. Cumulative exposure of long-term depressive symptoms in elderly individuals could predict accelerated subsequent cognitive decline in a dose-response pattern.Declaration of interestNone.
BACKGROUND: Little is known about the effect of persistent depressive symptoms on the trajectory of cognitive decline.AimsWe aimed to investigate the longitudinal association between the duration of depressive symptoms and subsequent cognitive decline over a 10-year follow-up period. METHOD: The English Longitudinal Study of Ageing cohort is a prospective and nationally representative cohort of men and women living in England aged ≥50 years. We examined 7610 participants with two assessments of depressive symptoms at wave 1 (2002-2003) and wave 2 (2004-2005), cognitive data at wave 2 and at least one reassessment of cognitive function (wave 3 to wave 7, 2006-2007 to 2014-2015). RESULTS: The mean age of the 7610 participants was 65.2 ± 10.1 years, and 57.0% were women. Of these, 1157 (15.2%) participants had episodic depressive symptoms and 525 participants (6.9%) had persistent depressive symptoms. Compared with participants without depressive symptoms at wave 1 and wave 2, the multivariable-adjusted rates of global cognitive decline associated with episodic depressive symptoms and persistent depressive symptoms were faster by -0.065 points/year (95% CI -0.129 to -0.000) and -0.141 points/year (95% CI -0.236 to -0.046), respectively (P for trend < 0.001). Similarly, memory, executive and orientation function also declined faster with increasing duration of depressive symptoms (all P for trend < 0.05). CONCLUSIONS: Our results demonstrated that depressive symptoms were significantly associated with subsequent cognitive decline over a 10-year follow-up period. Cumulative exposure of long-term depressive symptoms in elderly individuals could predict accelerated subsequent cognitive decline in a dose-response pattern.Declaration of interestNone.
Authors: Tomáš Formánek; Zsófia Csajbók; Katrin Wolfová; Matěj Kučera; Sarah Tom; Dag Aarsland; Pavla Cermakova Journal: Sci Rep Date: 2020-11-30 Impact factor: 4.379
Authors: Dorina Cadar; Jessica Abell; Fiona E Matthews; Carol Brayne; G David Batty; David J Llewellyn; Andrew Steptoe Journal: Int J Epidemiol Date: 2021-07-09 Impact factor: 7.196