Lucas Dall Agnol1, Fernanda Trindade Gonzalez Dias2, Natália Fontana Nicoletti3, Asdrubal Falavigna1,3, Otávio Bianchi1,2. 1. Health Sciences Postgraduate Program, University of Caxias do Sul (UCS), Caxias do Sul, Rio Grande do Sul, Brazil. 2. Materials Science Postgraduate Program, University of Caxias do Sul (UCS), Caxias do Sul, Rio Grande do Sul, Brazil. 3. Cell Therapy Laboratory (LATEC), University of Caxias do Sul (UCS), Caxias do Sul, Rio Grande do Sul, Brazil.
Abstract
AIM: Disc herniation is a spine disease that leads to suffering and disability. Discectomy is a Janus-faced approach that relieves pain symptoms but leave the intervertebral discs predisposed to herniation. This systematic review discussed the mechanical and biological requirements for a polyurethane-based biomaterial to be used in annular repair. METHODS: Search strategy was performed in PubMed, Web of Science and Scopus databases to define the main mechanical properties, biological findings and follow-up aspects of these biomaterials. The range was limited to articles published from January 2000 to December 2017 in English language. RESULTS: The search identified 82 articles. From these, a total of 18 articles underwent a full-text analysis, and 16 studies were included in the review. CONCLUSION: The polyurethane presents suitable properties to be used as an engineered solution to re-establish the microenvironment and biomechanical features of the intervertebral disc.
AIM: Disc herniation is a spine disease that leads to suffering and disability. Discectomy is a Janus-faced approach that relieves pain symptoms but leave the intervertebral discs predisposed to herniation. This systematic review discussed the mechanical and biological requirements for a polyurethane-based biomaterial to be used in annular repair. METHODS: Search strategy was performed in PubMed, Web of Science and Scopus databases to define the main mechanical properties, biological findings and follow-up aspects of these biomaterials. The range was limited to articles published from January 2000 to December 2017 in English language. RESULTS: The search identified 82 articles. From these, a total of 18 articles underwent a full-text analysis, and 16 studies were included in the review. CONCLUSION: The polyurethane presents suitable properties to be used as an engineered solution to re-establish the microenvironment and biomechanical features of the intervertebral disc.
Authors: J Du; R G Long; T Nakai; D Sakai; L M Benneker; G Zhou; B Li; D Eglin; J C Iatridis; M Alini; S Grad; Z Li Journal: Eur Cell Mater Date: 2020-01-03 Impact factor: 3.942