Brad Manor1,2,3, Junhong Zhou1,2,3, Rachel Harrison1, On-Yee Lo1,2,3, Thomas G Travison1,2,3, Jeffrey M Hausdorff4,5,6, Alvaro Pascual-Leone2,3,7, Lewis Lipsitz1,2,3. 1. 1 Institute for Aging Research, Hebrew SeniorLife, Roslindale, MA, USA. 2. 2 Beth Israel Deaconess Medical Center, Boston, MA, USA. 3. 3 Harvard Medical School, Boston, MA, USA. 4. 4 Center for the Study of Movement, Cognition, and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. 5. 5 Sagol School of Neuroscience and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 6. 6 Rush University Medical Center; Chicago, IL, USA. 7. 7 Universitat Autonoma de Barcelona, Barcelona, Spain.
Abstract
OBJECTIVE: To determine the effects of a transcranial direct current stimulation (tDCS) intervention with the anode placed over the left dorsolateral prefrontal cortex (dlPFC) and cathode over the right supraorbital region, on cognition, mobility, and "dual-task" standing and walking in older adults with mild-to-moderate motor and cognitive impairments. METHODS: A double-blinded, block-randomized, sham-controlled trial was conducted in 18 nondemented, ambulatory adults aged ⩾65 years with slow walking speed (⩽1.0 m/s) and "executive" dysfunction (Trail Making Test B score ⩽25th percentile of age- and education-matched norms). Interventions included ten 20-minute sessions of tDCS or sham stimulation. Cognition, mobility, and dual-task standing and walking were assessed at baseline, postintervention, and 2 weeks thereafter. Dual tasking was also assessed immediately before and after the first tDCS session. RESULTS:Intervention compliance was high (mean ± SD = 9.5 ± 1.1 sessions) and no unexpected or serious side effects were reported. tDCS, compared with sham, induced improvements in the Montreal Cognitive Assessment total score ( P = .03) and specifically within the executive function subscore of this test ( P = .002), and in several metrics of dual-task standing and walking ( P < .05). Each of these effects persisted for 2 weeks. tDCS had no effect on the Timed Up-and-Go test of mobility or the Geriatric Depression Scale. Those participants who exhibited larger improvements in dual-task standing posture following the first tDCS session exhibited larger cognitive-motor improvements following 2 weeks of tDCS ( P < .04). INTERPRETATION:tDCS intervention designed to stimulate the left dorsolateral prefrontal cortex may improve executive function and dual tasking in older adults with functional limitations.
RCT Entities:
OBJECTIVE: To determine the effects of a transcranial direct current stimulation (tDCS) intervention with the anode placed over the left dorsolateral prefrontal cortex (dlPFC) and cathode over the right supraorbital region, on cognition, mobility, and "dual-task" standing and walking in older adults with mild-to-moderate motor and cognitive impairments. METHODS: A double-blinded, block-randomized, sham-controlled trial was conducted in 18 nondemented, ambulatory adults aged ⩾65 years with slow walking speed (⩽1.0 m/s) and "executive" dysfunction (Trail Making Test B score ⩽25th percentile of age- and education-matched norms). Interventions included ten 20-minute sessions of tDCS or sham stimulation. Cognition, mobility, and dual-task standing and walking were assessed at baseline, postintervention, and 2 weeks thereafter. Dual tasking was also assessed immediately before and after the first tDCS session. RESULTS: Intervention compliance was high (mean ± SD = 9.5 ± 1.1 sessions) and no unexpected or serious side effects were reported. tDCS, compared with sham, induced improvements in the Montreal Cognitive Assessment total score ( P = .03) and specifically within the executive function subscore of this test ( P = .002), and in several metrics of dual-task standing and walking ( P < .05). Each of these effects persisted for 2 weeks. tDCS had no effect on the Timed Up-and-Go test of mobility or the Geriatric Depression Scale. Those participants who exhibited larger improvements in dual-task standing posture following the first tDCS session exhibited larger cognitive-motor improvements following 2 weeks of tDCS ( P < .04). INTERPRETATION: tDCS intervention designed to stimulate the left dorsolateral prefrontal cortex may improve executive function and dual tasking in older adults with functional limitations.
Authors: Felipe Fregni; Paulo S Boggio; Michael Nitsche; Felix Bermpohl; Andrea Antal; Eva Feredoes; Marco A Marcolin; Sergio P Rigonatti; Maria T A Silva; Walter Paulus; Alvaro Pascual-Leone Journal: Exp Brain Res Date: 2005-07-06 Impact factor: 1.972
Authors: Sudeshna A Chatterjee; Rachael D Seidler; Jared W Skinner; Paige E Lysne; Chanoan Sumonthee; Samuel S Wu; Ronald A Cohen; Dorian K Rose; Adam J Woods; David J Clark Journal: Neuromodulation Date: 2022-04-08
Authors: David J Clark; Sudeshna A Chatterjee; Jared W Skinner; Paige E Lysne; Chanoan Sumonthee; Samuel S Wu; Ronald A Cohen; Dorian K Rose; Adam J Woods Journal: Neuromodulation Date: 2020-08-18
Authors: On-Yee Lo; Mark A Halko; Kathryn J Devaney; Peter M Wayne; Lewis A Lipsitz; Brad Manor Journal: J Gerontol A Biol Sci Med Sci Date: 2021-09-13 Impact factor: 6.591