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Literature DB >> 3013184

Inhibition of cytochrome c oxidase by psychosine (galactosylsphingosine).

Abstract

Pi uptake and acetoacetate formation were suppressed by psychosine (galactosylsphingosine) in rat liver mitochondria. Besides, reduced form of cytochrome c increased in the reaction mixture which contained psychosine. Using reduced form of cytochrome c as substrate, less than 5 microM of psychosine (0.1 mumoles/mg of mitochondrial protein) inhibited cytochrome c oxidase by more than 50%. The inhibition was completely reversed by 1% human serum albumin. Thus, a lipid which is produced in the brain has a powerful and yet reversible inhibitory effect on an enzyme of cellular respiration.

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Year: 1986 PMID： 3013184 DOI： 10.1016/0006-291x(86)91213-1

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

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Cited

14 in total

Inhibition of cytochrome c oxidase by psychosine (galactosylsphingosine).

1. Factors that affect postnatal bone growth retardation in the twitcher murine model of Krabbe disease.

2. Binding of galactosylsphingosine (psychosine) by albumin.

Review 3. Twenty five years of the "psychosine hypothesis": a personal perspective of its history and present status.

4. Psychosine, the cytotoxic sphingolipid that accumulates in globoid cell leukodystrophy, alters membrane architecture.

5. The inhibition of a membrane-bound enzyme as a model for anaesthetic action and drug toxicity.

6. Psychosine is as potent an inducer of cell death as C6-ceramide in cultured fibroblasts and in MOCH-1 cells.

7. Physicochemical characterization of psychosine by 1H nuclear magnetic resonance and electron microscopy.

8. Biosynthesis of galactosylsphingosine (psychosine) in the twitcher mouse.

9. Kinetics of inhibition of purified and mitochondrial cytochrome c oxidase by psychosine (beta-galactosylsphingosine).

10. The iron(III)-adriamycin complex inhibits cytochrome c oxidase before its inactivation.