Tomohiro F Nishijima1, Allison M Deal2, Jennifer L Lund3, Kirsten A Nyrop4, Hyman B Muss5, Hanna K Sanoff6. 1. Lineberger Comprehensive Cancer Center, and University of North Carolina at Chapel Hill, Chapel Hill, North, Carolina, USA; Department of Medicine, Division of Hematology/Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North, Carolina, USA. Electronic address: tomohiro_nishijima@med.unc.edu. 2. Lineberger Comprehensive Cancer Center, and University of North Carolina at Chapel Hill, Chapel Hill, North, Carolina, USA. Electronic address: Allison_Deal@med.unc.edu. 3. Lineberger Comprehensive Cancer Center, and University of North Carolina at Chapel Hill, Chapel Hill, North, Carolina, USA; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North, Carolina, USA.. Electronic address: jennifer.lund@unc.edu. 4. Lineberger Comprehensive Cancer Center, and University of North Carolina at Chapel Hill, Chapel Hill, North, Carolina, USA; Department of Medicine, Division of Hematology/Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North, Carolina, USA. Electronic address: kirsten_nyrop@med.unc.edu. 5. Lineberger Comprehensive Cancer Center, and University of North Carolina at Chapel Hill, Chapel Hill, North, Carolina, USA; Department of Medicine, Division of Hematology/Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North, Carolina, USA. Electronic address: hyman_muss@med.unc.edu. 6. Lineberger Comprehensive Cancer Center, and University of North Carolina at Chapel Hill, Chapel Hill, North, Carolina, USA; Department of Medicine, Division of Hematology/Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North, Carolina, USA. Electronic address: hanna_sanoff@med.unc.edu.
Abstract
BACKGROUND: Our aim was to evaluate the prognostic impact of three inflammatory markers - neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR) and lymphocyte monocyte ratio (LMR) - on overall survival (OS) in older adults with cancer. MATERIALS AND METHODS: Our sample includes 144 patients age ≥ 65 years with solid tumor cancer who completed a cancer-specific Geriatric Assessment (GA) from 2010 to 2014 and had pretreatment CBC with differential. NLR was dichotomized a previously reported cut-off value of 3.5, while PLR and LMR were dichotomized at the median. Cox proportional hazards models evaluated whether NLR, PLR and LMR were predictive of OS independent of covariates including a recently developed 3-item GA-derived prognostic scale consisting of (1) "limitation in walking several blocks", (2) "limitation in shopping", and (3) "≥ 5% unintentional weight loss in 6 months". RESULTS: Median age was 72 years, 53% had breast cancer, 27% had stage 4 cancer, 14% had Karnofsky Performance Status (KPS) < 80, 11% received less intensive than standard treatment for stage, and 39% had NLR > 3.5. In univariable analysis, higher NLR and PLR and lower LMR were significantly associated with worse OS. NLR remained a significant predictor of OS (HR = 2.16, 95% CI; 1.10-4.25, p = .025) after adjusting for cancer type, stage, age, KPS, treatment intensity, and the GA-derived prognostic scale. CONCLUSION: NLR > 3.5 is predictive of poorer OS in older adults with cancer, independent of traditional prognostic factors and the GA-derived prognostic scale.
BACKGROUND: Our aim was to evaluate the prognostic impact of three inflammatory markers - neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR) and lymphocyte monocyte ratio (LMR) - on overall survival (OS) in older adults with cancer. MATERIALS AND METHODS: Our sample includes 144 patients age ≥ 65 years with solid tumor cancer who completed a cancer-specific Geriatric Assessment (GA) from 2010 to 2014 and had pretreatment CBC with differential. NLR was dichotomized a previously reported cut-off value of 3.5, while PLR and LMR were dichotomized at the median. Cox proportional hazards models evaluated whether NLR, PLR and LMR were predictive of OS independent of covariates including a recently developed 3-item GA-derived prognostic scale consisting of (1) "limitation in walking several blocks", (2) "limitation in shopping", and (3) "≥ 5% unintentional weight loss in 6 months". RESULTS: Median age was 72 years, 53% had breast cancer, 27% had stage 4 cancer, 14% had Karnofsky Performance Status (KPS) < 80, 11% received less intensive than standard treatment for stage, and 39% had NLR > 3.5. In univariable analysis, higher NLR and PLR and lower LMR were significantly associated with worse OS. NLR remained a significant predictor of OS (HR = 2.16, 95% CI; 1.10-4.25, p = .025) after adjusting for cancer type, stage, age, KPS, treatment intensity, and the GA-derived prognostic scale. CONCLUSION: NLR > 3.5 is predictive of poorer OS in older adults with cancer, independent of traditional prognostic factors and the GA-derived prognostic scale.
Authors: Hind A Beydoun; Sharmin Hossain; May A Beydoun; Jordan Weiss; Alan B Zonderman; Shaker M Eid Journal: J Periodontol Date: 2019-11-14 Impact factor: 4.494
Authors: Azadeh Nasrazadani; Juan Luis Gomez Marti; Kevin E Kip; Oscar C Marroquin; Lara Lemon; Steve D Shapiro; Adam M Brufsky Journal: Aging (Albany NY) Date: 2022-02-08 Impact factor: 5.682
Authors: Nikki Meijer; Daniël P de Bruyn; Annelies de Klein; Dion Paridaens; Robert M Verdijk; Tos T J M Berendschot; Erwin Brosens; Martine J Jager; Emine Kiliç Journal: Ophthalmol Sci Date: 2022-01-24