L Vansant1, M Cadenas De Llano-Pérula2, A Verdonck2, G Willems2. 1. Department of Oral Health Sciences - Orthodontics, KU Leuven and Dentistry, University Hospitals Leuven, Leuven, Belgium. Electronic address: Laure.vansant@uzleuven.be. 2. Department of Oral Health Sciences - Orthodontics, KU Leuven and Dentistry, University Hospitals Leuven, Leuven, Belgium.
Abstract
OBJECTIVES: The aim of the present systematic review was to offer a timeline of the events taking place during orthodontic tooth movement(OTM). MATERIALS AND METHODS: Electronic databases PubMed, Web of Science and EMBASE were searched up to November 2017. All studies describing the expression of signaling proteins in the periodontal ligament(PDL) of teeth subjected to OTM or describing the expression of signaling proteins in human cells of the periodontal structures subjected to static mechanical loading were considered eligible for inclusion for respectively the in-vivo or the in-vitro part. Risk of bias assessment was conducted according to the validated SYRCLE's RoB tool for animal studies and guideline for assessing quality of in-vitro studies for in-vitro studies. RESULTS: We retrieved 7583 articles in the initial electronic search, from which 79 and 51 were finally analyzed. From the 139 protein investigated, only the inflammatory proteins interleukin(IL)-1β, cyclooxygenase(COX)-2 and prostaglandin(PG)-E2, osteoblast markers osteocalcin and runt-related transcription factor(RUNX)2, receptor activator of nuclear factor kappa-B ligand(RANKL) and osteoprotegerin(OPG) and extracellular signal-regulated kinases(ERK)1/2 are investigated in 10 or more studies. CONCLUSION: The investigated proteins were presented in a theoretical model of OTM. We can conclude that the cell activation and differentiation and recruitment of osteoclasts is mediated by osteocytes, osteoblasts and PDL cells, but that the osteogenic differentiation is only seen in stem cell present in the PDL. In addition, the recently discovered Ephrin/Ephs seem to play an role parallel with the thoroughly investigated RANKL/OPG system in mediating bone resorption during OTM.
OBJECTIVES: The aim of the present systematic review was to offer a timeline of the events taking place during orthodontic tooth movement(OTM). MATERIALS AND METHODS: Electronic databases PubMed, Web of Science and EMBASE were searched up to November 2017. All studies describing the expression of signaling proteins in the periodontal ligament(PDL) of teeth subjected to OTM or describing the expression of signaling proteins in human cells of the periodontal structures subjected to static mechanical loading were considered eligible for inclusion for respectively the in-vivo or the in-vitro part. Risk of bias assessment was conducted according to the validated SYRCLE's RoB tool for animal studies and guideline for assessing quality of in-vitro studies for in-vitro studies. RESULTS: We retrieved 7583 articles in the initial electronic search, from which 79 and 51 were finally analyzed. From the 139 protein investigated, only the inflammatory proteins interleukin(IL)-1β, cyclooxygenase(COX)-2 and prostaglandin(PG)-E2, osteoblast markers osteocalcin and runt-related transcription factor(RUNX)2, receptor activator of nuclear factor kappa-B ligand(RANKL) and osteoprotegerin(OPG) and extracellular signal-regulated kinases(ERK)1/2 are investigated in 10 or more studies. CONCLUSION: The investigated proteins were presented in a theoretical model of OTM. We can conclude that the cell activation and differentiation and recruitment of osteoclasts is mediated by osteocytes, osteoblasts and PDL cells, but that the osteogenic differentiation is only seen in stem cell present in the PDL. In addition, the recently discovered Ephrin/Ephs seem to play an role parallel with the thoroughly investigated RANKL/OPG system in mediating bone resorption during OTM.
Authors: Maria Cadenas de Llano-Pérula; Chen Zong; Jeroen Van Dessel; Anne Marie Kuijpers-Jagtman; Guy Willems Journal: Clin Oral Investig Date: 2022-01-07 Impact factor: 3.573
Authors: Christian Behm; Michael Nemec; Alice Blufstein; Maria Schubert; Xiaohui Rausch-Fan; Oleh Andrukhov; Erwin Jonke Journal: Int J Mol Sci Date: 2021-01-20 Impact factor: 5.923
Authors: Erika Calvano Küchler; Suelyn Danielle Henklein; Peter Proff; César Penazzo Lepri; Camila Paiva Perin; Eva Paddenberg; Liliane Roskamp; Flares Baratto-Filho; Maria Angélica Hueb de Menezes-Oliveira; Christian Kirschneck Journal: Int J Environ Res Public Health Date: 2022-08-15 Impact factor: 4.614